In Vivo and In Silico Assessment of Diabetes Ameliorating Potentiality and Safety Profile of Gynura procumbens Leaves

Table 8

Activities of gluconeogenic enzymes in the kidney of control and experimental rats.

Group	Glucose-6-phosphatase (n moles of Pi liberated/min/mg protein)	Fructose-1,6-diphosphatase (n moles of Pi liberated/min/mg protein)
C	50.74 ± 4.03	22.1 ± 2.98
A	129.18 ± 5.10	219.88 ± 5.13
A + M100	70.2 ± 7.45^∗	40.32 ± 4.39^∗
A + M200	59.8 ± 5.16^∗	33.62 ± 4.29^∗
A + M500	48.12 ± 1.71^∗	26.02 ± 1.60^∗
A + G500	74.08 ± 9.51^∗	45.16 ± 5.74^∗
A + G750	62.12 ± 6.09^∗	38.94 ± 3.38^∗
A + G1000	49.14 ± 2.58^∗	34.24 ± 4.46^∗
M100	52.18 ± 4.56	22.1 ± 2.99
M200	50.16 ± 2.9	20.64 ± 2.38
M500	49.38 ± 1.94	24.38 ± 2.22
G500	50.94 ± 3.40	21.04 ± 3.49
G750	51.04 ± 3.80	19.54 ± 1.84
G1000	51.34 ± 3.09	21.54 ± 2.45

^∗ indicates a significant difference from the disease group (C = control group, A = alloxan-treated group, M = metformin, A + M = alloxan + metformin, A + G = alloxan + Gynura, and G = G. procumbens).