| | Author, year | Trials (subjects) | Intervention Group | Control Group | Quality Assessment | Main Results |
| | Guo-zhong Yi, 2014 [25] | 14 (1, 116) | XFZY + CT, XFZY | CT, CT + Placebo | Cochrane Criteria | XFZY combined with CT is more effective than CT alone in improving the clinical symptoms of patients with angina pectoris, especially in patients with stable angina pectoris. | | Shiqi Chen, 2022 [26] | 16 (1, 171) | XFZY + CT | CT | Cochrane Criteria | In summary, this analysis suggests that XFZY can be used as a representative herbal formula with important clinical applications in improving cardiac and endothelial function as well as LVEF, LVEDD, LVESD, NO, ET-1, and ICAM-1 in acute coronary syndrome. | | Shuo Zhang, 2021 [27] | 30 (3, 126) | XFZY + CT, XFZY | CT | Cochrane Criteria | XFZY can treat CHD through the combined effect of multiple drugs with significant efficacy and no significant adverse effects. And according to the results, XFZY is more suitable for patients with CHD who have clinical indications such as dyslipidemia, high blood viscosity or vascular endothelial dysfunction. | | Xiaochen Yang, 2014 [28] | 8 (534) | XFZY + CT, XFZY | CT, CT + Placebo | Cochrane Criteria | Our systematic evaluation suggests that XFZY in combination with CT may have good effects in reducing angina symptoms and improving ECG with few side effects in patients with unstable angina. However, due to the low quality of included trials, no clear conclusions could be drawn. Future more rigorously designed randomized controlled trials with large samples should be conducted. | | Zhou Fang, 2016 [29] | 22 (1, 951) | XFZY | CT | Cochrane Criteria | Although the present study presents consistent results that XFZY may be more effective than nitrates in the treatment of angina pectoris | | Huai Guo, 2017 [30] | 12 (1, 252) | XFZY + CT | CT | Cochrane Criteria | In conclusion, XFZY was effective in the adjuvant treatment of unstable angina and significantly improved lipid and inflammatory factor levels in patients. | | Jinfeng Liu, 2020 [31] | 9 (592) | XFZY + CT | CT | Jadad | The results showed that the efficacy of XFZY plus/minus combined with conventional Western medicine in the treatment of angina pectoris in CHD was better than that of conventional Western medicine, which confirmed the advantages of combined Western and Chinese medicine in the treatment of CHD. | | Min Liu, 2016 [32] | 8 (598) | XFZY + CT, XFZY | CT | Jadad | XFZY has achieved some efficacy in the treatment of stable angina pectoris. | | Yun Liu, 2017 [33] | 9 (837) | XFZY + CT | CT | Cochrane Criteria | This systematic review shows that XFZY combined with western medicine is superior to conventional western medicine in the treatment of CHD. | | Yao Meng, 2021 [34] | 11 (980) | XFZY + CT | CT | Jadad | On the basis of CT, the application of XFZY adjuvant treatment of CHD has a significant effect, which can effectively relieve the symptoms of angina pectoris and improve blood lipid levels. | | Guohua Zheng, 2012 [35] | 14 (1, 001) | XFZY + CT, XFZY | CT | Jadad | The combination of XFZY and CT can significantly reduce the symptoms of angina pectoris and improve the electrocardiogram in patients with CHD, with few adverse reactions. |
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