Amelioration of Hypertension by Oryeongsan through Improvements of Body Fluid and Sodium Balance: Roles of the Renin-Angiotensin System and Atrial Natriuretic Peptide System

Figure 1

Changes in renal function in Sham-operated normotensive (Sham) and two-kidney, one-clip (2K1C) hypertensive rats treated with vehicle (H) (a) and H and 2K1C hypertensive rats treated with Oryeongsan (ORS) (H + ORS) (b). ○, Sham; , H; , H + ORS. Vehicle, distilled water, 1 ml/rat/day, or ORS, 100 mg/kg/day orally, administered for 3 weeks after 4 weeks of operation. UV, urine volume; Uosm, urinary osmolality; UNaV, urinary excretion of Na⁺; UClV, urinary excretion of Cl⁻; UKV, urinary excretion of K⁺; UCrV, urinary excretion of creatinine. Number of experiments: Sham (Sham + vehicle), n = 8; H (2K1C + vehicle), n = 9; H + ORS, n = 8. Many of the standard error bars are embedded in the markings of the mean values. Small numerals above or below markings of the mean values are values; 1, ; 2, ; 3, versus Sham or H.

(a)

(b)