Research Article
Amelioration of Hypertension by Oryeongsan through Improvements of Body Fluid and Sodium Balance: Roles of the Renin-Angiotensin System and Atrial Natriuretic Peptide System
Figure 2
Summarized effects of Oryeongsan (ORS) on the urinary volume (UV), osmolality (Uosm), and Na+ excretion (UNaV) (a), water and Na+ balance (b), and the relation between glomerular filtration rate (GFR, CCr) and UNaV (c) in Sham (S) and 2K1C hypertensive (H) rats treated with vehicle or ORS. CCr, clearance for creatinine (GFR). Number of experiments: Sham + vehicle (S) or S + ORS, n = 8 for each group; H + vehicle (H), n = 9; H + ORS, n = 8. , , and versus Sham; ## and ### versus H. C, control values of 2 control days, day 1 and day 0; week 1, the first week of ORS administration, days 1–3 and 5–7 (6 days); week 2, the second week of ORS administration, days 8, 9, and 11–14 (6 days); week 3, the third week of ORS administration, days 15, 16, and 18–21 (6 days). Days 4, 10, and 17 were for blood pressure measurements and no urine collection.
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