Amelioration of Hypertension by Oryeongsan through Improvements of Body Fluid and Sodium Balance: Roles of the Renin-Angiotensin System and Atrial Natriuretic Peptide System

Figure 4

Effects of Oryeongsan (ORS) on the gene expression levels of vasopressin V₂ receptor (V₂R) and aquaporin AQP2 in the renal medulla from Sham (S) and hypertensive (H) rats. Open bar, vehicle-treated; closed bar, ORS-treated. Number of experiments: for gene expression of AQP2 and V2R (left and right kidneys), n = 3 for each of the Sham groups and n = 4 for each of the hypertensive groups. Sham + vehicle (S-) or Sham + ORS (S+); 2K1C + vehicle (H-); 2K1C + ORS (H+). , , and versus Sham; ## and ### versus H. In gene expression of the hypertensive group (H), there are 2 open bars in succession with different meanings: the first one is gene expression to be normalized compared to S- (Sham group treated with vehicle), and the other is to be normalized compared to H- (the hypertensive group treated with vehicle).