Amelioration of Hypertension by Oryeongsan through Improvements of Body Fluid and Sodium Balance: Roles of the Renin-Angiotensin System and Atrial Natriuretic Peptide System

Figure 5

Effects of Oryeongsan (ORS) on the gene expression of the ACE, ACE2, AT₁ receptor, AT₂ receptor, and Mas receptor in the cortex of the kidneys from Sham (S) and hypertensive (H) rats (a) and ACE, AT1 receptor, AT2 receptor, and Mas receptor in the medulla of the kidneys from hypertensive rats (b). Number of experiments: n = 4 for mRNA expression of the ACE, AT1R, ACE2, AT2 receptor, and Mas receptor (a) in the left (A) and right (B) kidneys; n = 8-9 for mRNA expression of the ACE, AT1R, AT2 receptor, and Mas receptor in the left (A) and right (B) kidneys from hypertensive rats (b). Open bar, vehicle (-ORS); closed bar, ORS-treated (+ORS). In gene expression (a), there are 2 open bars in succession with different meanings in hypertensive rats treated with vehicle (H-): the first one is gene expression to be normalized compared to S- (Sham group treated with vehicle), and the other is to be normalized compared to H- (Hypertensive group treated with vehicle). , , and versus Sham (S-); ## and ### versus H-.

(a)

(b)