Pharmacological Mechanism of Shen Huang Chong Ji for Treating Alzheimer’s Disease Based on Network Pharmacology and Experimental Validation

Table 1

Central coordinates of the protein and the parameters of the docking region.

Gene name	PDB ID	Grid box
		Center coordinates (X, Y, Z)	Size parameters (X, Y, Z)
HSP90AA1	6tn5	32.311, 14.712, 20.285	50.0, 52.0, 52.0
AKT1	3mv5	2.29, −0.721, 25.379	66.0, 58.0, 70.0
MAPK1	3sa0	−2.025, 8.346, 46.564	66.0, 52.0, 78.0
JUN	1jnm	15.865, 3.428, 29.021	32.0, 40.0, 96.0
RELA	6qhl	23.715, 12.347, 8.034	58.0, 64.0, 58.0
MAPK14	3lff	11.153, −4.657, −17.657	76.0, 52.0, 62.0
ESR1	3os8	21.44, 8.134, −68.509	62.0, 40.0, 62.0
FOS	1s9k	26.55, 23.416, 65.415	86.0, 72.0, 96.0
IL-6	4ni9	2.884, 21.709, 8.078	58.0, 56.0, 56.0
MYC	5i4z	20.53, 26.142, 9.853	92.0, 38.0, 32.0
CDKN1A	5e0u	−45.634, 41.642, −12.013	46.0, 74.0, 60.0
RB1	2qdj	6.335, 35.71, 20.609	60.0, 72.0, 74.0
Caspase 3	3kjf	4.344, 6.913, 2.268	74.0, 70.0, 54.0
Caspase 9	2ar9	16.849, 40.99, 0.996	46.0, 58.0, 58.0
Caspase 8	3kjn	−3.27, 29.642, 27.204	56.0, 60.0, 70.0
BAX	4bd6	−17.863, −14.654, −3.905	84.0, 72.0, 58.0
Bcl2	1ysw	2.222, -4.204, 3.104	54.0, 56.0, 40.0