Structural and Functional Properties of Activator Protein-1 in Cancer and Inflammation

Figure 1

Structure of activator protein (AP)-1. The carboxy-terminal regions of α-helixes align to form parallel “coiled coils”, while the amino-terminal regions make base-specific contacts with DNA in the major groove (PDB code 1Fos). Coils forming leucine zipper in blue and pink are c-Fos and c-Jun, respectively.