Effects of Jie Yu Wan on Generalized Anxiety Disorder: A Randomized Clinical Trial

Table 2

Primary outcome analyses (the HAMA total score).

	n	JYW, mean (SD)	n	Buspirone, mean (SD)	F
Model 1	49		50
Baseline		18.8 (3.73)		19.14 (3.66)
1 week		16.31 (3.60)		16.58 (3.83)
2 weeks		13.37 (4.00)		13.72 (4.82)
4 weeks		10.31 (4.56)		11.06 (5.02)
8 weeks		6.67 (4.00)		8.14 (4.62)
Time effect		…		…	300.36	0.001
Group effect		…		…	0.78	0.38
Grouptime^a		…		…	0.78	0.38
Model 2	66		67
baseline		18.95 (4.07)		19.09 (3.92)
1 week		16.65 (4.15)		16.58 (4.07)
2 weeks		14.14 (4.72)		14.85 (5.31)
4 weeks		11.91 (6.09)		12.58 (6.02)
8 weeks		9.21 (6.70)		10.28 (4.68)
Time effect		…		…	193.54	0.001
Group effect		…		…	0.55	0.46
Grouptime^a		…		…	0.49	0.57
Model 3	53	10.79 (5.60)	54	11.00 (5.15)	−0.20	0.84
Model 4	53	10.79 (5.59)	54	5.3 (5.15)	5.27	0.001

Data are presented as mean (SD). The adjusted proportional difference can be interpreted as the difference in scores between the randomized groups, expressed as a proportion (or percentage). Model 1: primary analysis model, includes data for participants who completed the entire study (n = 99). Model 2: ITT analysis conducted on the FAS (n = 133). Model 3: sensitivity analyses (n = 108). Model 4: noninferiority test and analysis (n = 108). ^aInteraction effect between group and time.