Effects of Jie Yu Wan on Generalized Anxiety Disorder: A Randomized Clinical Trial

Table 3

Repeated measures analyses of continuous secondary outcomes at weeks 1–8.

	JYW, mean (SD) (n = 66)	Buspirone, mean (SD) (n = 67)	F
HAMD
Baseline	6.75 (0.20)	6.95 (0.20)
1 week	5.88 (0.18)	6.12 (0.18)
2 weeks	4.99 (0.23)	5.17 (0.23)
4 weeks	3.91 (0.30)	4.46 (0.30)
8 weeks	3.02 (0.29)	3.25 (0.29)
Time effect	…	…	90.79	0.001
Group effect	…	…	0.71	0.40
Grouptime^a	…	…	0.22	0.82
CGI
Baseline	…	…
1 week	3.42 (0.61)	3.45 (0.63)
2 weeks	2.95 (0.62)	3.09 (0.85)
4 weeks	2.56 (0.95)	2.60 (0.95)
8 weeks	2.17 (1.13)	2.24 (1.14)
Time effect	…	…	146.16	0.001
Group effect			0.26	0.61
Grouptime^a	…	…	0.31	0.73
TCM syndrome
Baseline	102.42 (38.12)	99.52 (42.39)
1 week	89.94 (37.32)	89.43 (40.47)
2 weeks	77.35 (37.65)	79.90 (42.81)
4 weeks	67.53 (40.81)	68.60 (43.91)
8 weeks	55.58 (42.83)	57.84 (44.72)
Time effect	…	…	156.81	0.001
Group effect			0.01	0.94
Grouptime^a	…	…	0.66	0.50

^aInteraction effect between group and time.