Pharmacological Characteristics of the Hydroethanolic Extract of Acmella oleracea (L) R. K. Jansen Flowers: ADME/Tox In Silico and In Vivo Antihypertensive and Chronic Toxicity Evaluation

Table 5

Prediction of pharmacokinetics parameters of the phytochemicals found in the hydroethanolic extract of flowers of A. oleracea.

Lipophilicity	Spilanthol	D-limonene	Scopoletin
Log Po/w (iLOGP)	3.55	2.72	1.86
Log Po/w (XLOGP3)	3.57	4.57	1.53
Log Po/w (WLOGP)	3.23	3.31	1.51
Log Po/w (MLOGP)	2.99	3.27	0.76
Log Po/w (SILICOS-IT)	3.49	2.97	1.94
Consensus log Po/w	3.36	3.37	1.52
Water solubility
Log S (ESOL)	−2.93	−3.50	−2.46
Log S (Ali)	−3.87	−4.29	−2.39
Log S (SILICOS-IT)	−2.58	−2.26	−3.17
Consensus log S	−3.12	−3.35	−2.67