Pharmacological Characteristics of the Hydroethanolic Extract of Acmella oleracea (L) R. K. Jansen Flowers: ADME/Tox In Silico and In Vivo Antihypertensive and Chronic Toxicity Evaluation

Table 6

Prediction of biological activity of promising the major compounds found in the hydroethanolic extract of flowers of A. oleracea via PASS online.

Prediction of biological activity	Spilanthol		D-limonene		Scopoletin
	Pa	Pi	Pa	Pi	Pa	Pi
Respiratory analeptic	—	—	0.716	0.014	—	—
TP53 expression enhancer	—	—	—	—	0.805	0.010
Antieczematic	0.703	0.044	0.896	0.005	—	—
CYP2J2 substrate	0.720	0.028	—	—	—	—
Fatty-acyl-CoA synthase inhibitor	0.730	0.009	—	—	—	—
Testosterone 17beta-dehydrogenase (NADP+) inhibitor	0.751	0.039	0.753	0.038	0.707	0.053
Ubiquinol-cytochrome-c reductase inhibitor	0.765	0.045	0.707	0.066	0.829	0.023
Chymosin inhibitor	0.796	0.021	—	—	—	—
Saccharopepsin inhibitor	0.796	0.021	—	—	—	—
Acrocylindropepsin inhibitor	0.796	0.021	—	—	—	—
CYP2J substrate	0.796	0.022	0.747	0.035	—	—
Mucomembranous protector	0.801	0.018	—	—	—	—
Phobic disorders treatment	0.821	0.026	—	—	—	—