Prevention of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice by Bilobalide

Figure 1

Bilobalide attenuated BLM-induced pulmonary fibrosis in mice. (a) The murine pulmonary fibrosis model was induced with BLM of 2.5 mg/kg, and different doses of bilobalide were administered intraperitoneally after 2 hours. (b) After 21 days, all mice were executed, and the lung samples were excised and photographed. (c) Lung/body weight index. (d) Representative images of H&E lung sections (scale bar = 100 μm). (e) Histological score of H&E staining. (f) Masson trichrome staining of lung sections. Blue color indicates fibrosis (scale bar = 50 μm). (g) Fibrosis score based on Masson staining. (h) Lung hydroxyproline content. Data were reported as means ± SD, n = 6. vs. control, ^# vs. BLM, ^## vs. BLM. BLM, bleomycin. H&E, hematoxylin and eosin. SD, standard deviation.

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