Krüppel-Like Factor 2 Is a Gastric Cancer Suppressor and Prognostic Biomarker

<div>KLF2 expression is low in GC tissues. (a) TIMER2.0 database used to analyze mRNA levels of KLF2 in different tumor types. (b) KLF2 expression levels in different tumor cell lines detected by the CCLE database. (c) The TCGA database used to analyze KLF2 expression in GC tissues and paired adjacent noncancerous tissues. (d) The GEPIA database used to determine KLF2 expression in GC tissue and normal tissue data. (e) mRNA levels of KLF2 detected by RT-qPCR in GC tissues and paired adjacent noncancerous tissues (<i>n</i> = 30). (f) IHC used to analyze KLF2 protein levels in GC tissue microarrays. <span class="nowrap"><svg height="9.2729pt" id="M2" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.6359 44.8393 9.2729" width="44.8393pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.658,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.921,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 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Evidence-Based Complementary and Alternative Medicine

fig1

Figure 1

Figure 1: Krüppel-Like Factor 2 Is a Gastric Cancer Suppressor and Prognostic Biomarker 