Hypoglycemic and Hypotensive Effects of Calycotome villosa Subsp. intermedia Seeds in Meriones shawi Rats: In Vivo, Ex Vivo, and In Vitro Investigations
Table 4
Effect of daily oral administration of the CV extract on creatinine, urea, and urinary volume in normal and treated animals.
Parameters
Treatment duration (weeks)
Experimental groups
HCD/SLS + DW
NC + DW
NC + CV
HCD/SLS + CV
HCD/SLS + (Aml + )
Creatinine (mg/dL)
0
78.73 ± 0.21
79.98 ± 0.24
78.58 ± 0.21
76.92 ± 0.28
100.97 ± 0.13
1
74.53 ± 0.14
78.88 ± 0.19
75.94 ± 0.35
78.34 ± 0.09
110.52 ± 0.10
2
80.76 ± 0.28
78.64 ± 0.07
80.37 ± 0.63
92.16 ± 0.16
3
84.22 ± 0.10
83.25 ± 0.42
Urea (mg/dL)
0
1171.06 ± 5.65
1124.88 ± 4.24
1122.12 ± 4.94
1201.45 ± 4.42
1096.63 ± 7.16
1
1061.07 ± 7.77
1107.56 ± 7.62
1145.32 ± 3.53
1247.42 ± 5.65
2
1120.41 ± 4.24
1140.99 ± 2.82
1158.28 ± 6.18
3
1083.66 ± 8.48
UV (mL/dL)
0
8.71 ± 0.04
12.19 ± 0.28
12.61 ± 0.12
8.24 ± 0.13
9.21 ± 0.11
1
12.55 ± 0.10
12.18 ± 0.07
2
12.27 ± 0.21
12.13 ± 0.16
3
12.55 ± 0.14
12.41 ± 0.09
a: comparison of variables between the week 0 and all weeks, b: comparison between the normal group and all groups at week 3, c: between the diabetic group and the treated diabetic group at week 3 (,, and ).
