Efficacy of Kami Guibi-tang as an Add-On Therapy to Acetylcholinesterase Inhibitor for Cognitive Function in Mild Alzheimer’s Disease: A Pilot Study
Table 4
Changes in SNSB subscores, KQOL-AD, and CGA-NPI scores between baseline and 24th-weekfollow-up.
Variable
KGT (n = 9)
Placebo (n = 7)
‡ value for treatment difference
Baseline
24th week
Change
† value
Baseline
24th week
Change
† value
K-MMSE
22.86 ± 3.67, 22.00 (6.00)
20.29 ± 3.50, 20.00 (7.00)
−2.57 ± 1.51, −2.00 (2.00)
0.03
21.00 ± 2.71, 21.00 (2.00)
17.57 ± 3.82, 17.00 (7.00)
−3.43 ± 3.31, −3.00 (2.00)
0.03
0.80
SGDS
6.29 ± 3.68, 4.00 (5.00)
5.00 ± 4.58, 4.00 (6.00)
−1.29 ± 2.29, −1.00 (3.00)
0.25
1.83 ± 2.64, 1.00 (2.00)
1.43 ± 1.90, 1.00 (3.00)
−0.67 ± 3.61, −0.50 (2.00)
0.81
0.62
Barthel-ADL
20.00 ± 0.00, 20.00 (0.00)
19.71 ± 0.76, 20.00 (0.00)
−0.29 ± 0.76, 0.00 (0.00)
1.00
19.29 ± 1.50, 20.00 (1.00)
19.43 ± 0.79, 20.00 (1.00)
0.14 ± 1.86, 0.00 (1.00)
1.00
1.00
K-IADL
0.65 ± 0.39, 0.56 (0.73)
0.86 ± 0.44, 0.80 (0.72)
0.20 ± 0.29, 0.11 (0.61)
0.09
1.13 ± 0.69, 1.00 (1.06)
1.00 ± 0.62, 1.11 (1.04)
−0.12 ± 0.65, −0.11 (0.49)
0.50
0.20
CDR-GS
1.00 ± 0.00, 1.00 (0.00)
0.93 ± 0.19, 1.00 (0.00)
−0.07 ± 0.19, 0.00 (0.00)
1.00
1.00 ± 0.00, 1.00 (0.00)
1.00 ± 0.00, 1.00 (0.00)
0.00 ± 0.00, 0.00 (0.00)
—
0.41
CDR-SB
4.86 ± 1.13, 4.50 (1.00)
5.00 ± 1.61, 5.00 (2.50)
0.14 ± 0.69, 0.00 (1.50)
0.53
5.50 ± 1.58, 5.00 (1.00)
5.86 ± 0.69, 6.00 (1.00)
0.36 ± 1.28, 1.00 (2.00)
0.56
0.45
GDS
4.71 ± 0.49, 5.00 (1.00)
4.71 ± 0.49, 5.00 (1.00)
0.00 ± 0.00, 0.00 (0.00)
—
4.86 ± 0.38, 5.00 (0.00)
4.86 ± 0.38, 5.00 (0.00)
0.00 ± 0.00, 0.00 (0.00)
—
1.00
KQOL-AD
Patients
31.14 ± 5.58, 28.00 (10.00)
28.57 ± 4.85, 29.00 (9.00)
−2.57 ± 4.42, −2.00 (4.00)
0.16
34.29 ± 6.60, 35.00 (10.00)
34.14 ± 5.21, 32.00 (9.00)
−0.14 ± 8.93, −2.00 (15.00)
1.00
0.61
Caregivers
27.86 ± 5.11, 26.00 (6.00)
27.00 ± 7.48, 25.00 (11.00)
−0.86 ± 5.24, −3.00 (8.00)
0.58
30.57 ± 7.52, 33.00 (16.00)
29.86 ± 4.56, 29.00 (7.00)
−0.71 ± 5.44, 1.00 (8.00)
1.00
0.66
CGA-NPI
6.86 ± 5.30, 8.00 (12.00)
11.14 ± 8.84, 10.00 (9.00)
4.29 ± 6.34, 2.00 (9.00)
0.19
7.00 ± 8.14, 3.00 (12.00)
9.86 ± 12.62, 4.00 (12.00)
2.86 ± 14.95, 3.00 (24.00)
0.72
1.00
KGT, Kami Guibi-tang; SNSB-D, Seoul Neuropsychological Screening Battery-Dementia Version; K-MMSE, Korean Mini-Mental State Examination; SGDS, Short Geriatric Depression Scale; Barthel-ADL, Barthel Activities of Daily Living; K-IADL, Korean-Instrumental Activities of Daily Living; CDR-SB, Clinical Dementia Rating Scale–Sum of Boxes; CDR-GS, Clinical Dementia Rating Scale-Global Score; GDS, Global Deterioration Scale; KQoL-AD, Korean version of Quality of Life-Alzheimer’s disease; CGA-NPI, Caregiver-Administered Neuropsychiatric Inventory. Values are presented as mean ± standard deviation, median (interquartile range). †Based on Wilcoxon signed rank test. ‡Based on Wilcoxon rank sum test.
