Efficacy of Kami Guibi-tang as an Add-On Therapy to Acetylcholinesterase Inhibitor for Cognitive Function in Mild Alzheimer’s Disease: A Pilot Study
Table 6
Changes in SNSB-D subscores between baseline and 24th-weekfollow-up with the aMCI group.
Variable
Mild AD (n = 7)
aMCI (n = 16)
‡ value for treatment difference
Baseline
24th week
Change
† value
Baseline
24th week
Change
† value
K-MMSE
22.86 ± 20.29, 22.00 (6.00)
20.29 ± 3.50, 20.00 (7.00)
−2.57 ± 1.51, −2.00 (2.00)
0.03
27.63 ± 1.82, 28.50 (2.50)
27.94 ± 1.65, 28.00 (3.00)
0.31 ± 1.78, 0.50 (1.50)
0.58
0.01
SGDS
6.29 ± 3.68, 4.00 (5.00)
5.00 ± 4.58, 4.00 (6.00)
−1.29 ± 2.29, −1.00 (3.00)
0.25
5.75 ± 5.29, 4.00 (9.00)
4.06 ± 4.42, 2.00 (7.00)
−1.69 ± 5.12, −2.00 (4.50)
0.07
0.84
Barthel-ADL
20.00 ± 0.00, 20.00 (0.00)
19.71 ± 0.76, 20.00 (0.00)
−0.29 ± 0.76, 0.00 (0.00)
1.00
20.00 ± 0.00, 20.00 (0.00)
20.00 ± 0.00, 20.00 (0.00)
0.00 ± 0.00, 0.00 (0.00)
—
0.17
K-IADL
0.65 ± 0.39, 0.56 (0.73)
0.86 ± 0.44, 0.80 (0.72)
0.20 ± 0.29, 0.11 (0.61)
0.10
0.13 ± 0.06, 0.10 (0.09)
0.11 ± 0.04, 0.09 (0.01)
−0.02 ± 0.06, 0.00 (0.00)
0.44
0.02
CDR-GS
1.00 ± 0.00, 1.00 (0.00)
0.93 ± 0.19, 1.00 (0.00)
−0.07 ± 0.19, 0.00 (0.00)
1.00
0.50 ± 0.00, 0.50 (0.00)
0.34 ± 0.24, 0.50 (0.50)
−0.16 ± 0.24, 0.00 (0.50)
0.06
0.44
CDR-SB
4.86 ± 1.03, 4.50 (1.00)
5.00 ± 1.61, 5.00 (2.50)
0.14 ± 0.69, 0.00 (1.50)
0.53
1.53 ± 0.64, 1.50 (1.00)
1.13 ± 0.62, 1.00 (1.00)
−0.41 ± 0.55, −0.25 (0.50)
0.01
0.17
GDS
4.71 ± 0.49, 5.00 (1.00)
4.71 ± 0.49, 5.00 (1.00)
0.00 ± 0.00, 0.00 (0.00)
—
3.00 ± 0.00, 3.00 (0.00)
2.69 ± 0.48, 3.00 (1.00)
−0.31 ± 0.48, 0.00 (1.00)
0.06
0.13
KGT, Kami Guibi-tang; SNSB-D, Seoul Neuropsychological Screening Battery-Dementia Version; K-MMSE, Korean version Mini-Mental State Examination; SGDS, Short Geriatric Depression Scale; Barthel-ADL, Barthel Activities of Daily Living; K-IADL, Korean-Instrumental Activities of Daily Living; CDR-SB, Clinical Dementia Rating Scale–Sum of Boxes; CDR-GS, Clinical Dementia Rating Scale-Global Score; GDS, Global Deterioration Scale. Values are presented as mean ± standard deviation, median (interquartile range). †Based on Wilcoxon signed rank test. ‡Based on Wilcoxon rank sum test. values in bold represent significance, was considered statistically significant.
