Rutin and Hesperidin Alleviate Paclitaxel-Induced Nephrocardiotoxicity in Wistar Rats via Suppressing the Oxidative Stress and Enhancing the Antioxidant Defense Mechanisms

Table 3

Pathological renal lesion scores in different groups.

Groups	Parameters
	Degenerative renal tubules	Necrosis of renal tubules	Congestion	Leucocytic infiltration	Glomerulonephrosis
Normal	−	−	−	−	−
Paclitaxel	++	++	+++	+++	+++
Paclitaxel + rutin	++	−	++	++	++
Paclitaxel + hesperidin	++	+	++	++	+++
Paclitaxel + rutin + hesperidin	++	+	+++	+	++

Lesion types are (−) absence, (+) minimal, (++) mild, (+++) moderate, and (++++) severe.