Rutin and Hesperidin Alleviate Paclitaxel-Induced Nephrocardiotoxicity in Wistar Rats via Suppressing the Oxidative Stress and Enhancing the Antioxidant Defense Mechanisms

Table 4

Pathological cardiac lesion scores in different groups.

Groups	Parameters
	Coagulative necrosis (hyalinosis)	Leucocytic infiltration
Normal	−	−
Paclitaxel	++	+++
Paclitaxel + rutin	+	+
Paclitaxel + hesperidin	++	−
Paclitaxel + rutin + hesperidin	+	−

Lesion types are (−) absence, (+) minimal, (++) mild, (+++) moderate, and (++++) severe.