Xuanhuang Runtong Tablets Relieve Slow Transit Constipation in Mice by Regulating TLR5/IL-17A Signaling Mediated by Gut Microbes

Figure 2

XHRT improved intestinal transit in mice with slow transit constipation induced by loperamide hydrochloride. (a) Comparison of fecal dry weight on day 0 and 7 days after loperamide induction. (b) Changes in body weight of mice at 0 d, 7 d, and 14 d. (c) The effect of XHRT on the time to discharge the first black stool in STC mice, (d) the number of black stools discharged within six hours, and (e) the water content of stool in 6 hours. (f–h) The effect of XHRT on the small intestine transport of STC mice was evaluated by the ink intestinal propulsion exercise. (f) The total length of the small intestine, (g) the length of ink advancing in the small intestine, and (h) the small intestine transport rate. STC: slow transit constipation; XHRT: Xuanhuang Runtong tablet; values are expressed as the mean ± SD, vs. control group; , vs. STC model group.

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