Xuanhuang Runtong Tablets Relieve Slow Transit Constipation in Mice by Regulating TLR5/IL-17A Signaling Mediated by Gut Microbes

Figure 4

XHRT regulated the structure of the intestinal microbial community in STC mice induced by loperamide hydrochloride. (a) Venn diagram representing the number of OTUs identified in the gut microbiome of STC mice treated with XHRT; mice treated with different doses of XHRT (4.056, 2.028, and 1.014 g/kg) were designated as XHRT-H, XHRT-M, and XHRT-L groups and 16S rDNA microbial gene sequencing. (b) The sparse curve was established based on the Chao1 index of 16S rDNA microbial analysis. (c) PLS-DA analysis based on the full OTUs level. XHRT-H, -M, and -L: Xuanhuang Runtong tablet high dosage, medium dosage, and low dosage. PLS-DA: partial least squares regression analysis method.

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