Pharmacological Effects of Genistein on Cardiovascular Diseases

Table 2

The effects of genistein on cardio toxicity.

Study Design	Doses	Route of administration	Effects	Ref
Adult rat ventricular myocytes	20 microM	Dietary intake	↓Glucose toxicity-induced cardiac mechanical dysfunction	[38]
Guinea pig model	—	Chronic: daily subcutaneous injection for 10 days; Acute: intraperitoneal injection 1 hour before endotoxic shock	↑plasma nitrate concentration; ↑cGMP; ↓APD	[39]
Mice	5 mg/kg	Injection	↓Expressions of IL-6, IL-8, TNF-α; ↑Protein expressions of HO-1, Nrf-2, NQO1; ↓Apoptosis	[40]
Diabetic rats	300 mg/kg/day	Administered po for 24 weeks	↓Blood glucose; ↓HbA1c; ↓C-reactive protein; ↓Expression of TNF-α; ↓TGF-β1 proteins; ↑Total antioxidant	[41]
Mice	(0.25, 0.5 or 1 mg/kg)	intraperitoneal injection	↓Burn-induced myocardial injury; ↑LVEF; ↓Lactate dehydrogenase; ↓level of creatine kinase; ↓Apoptosis; ↓Inducible NO synthase; ↓NO and superoxide anions production; ↑Expression of Hes1 and NICD1; ↓Burn-induced myocardial injury; ↓Oxidative/nitrative stress	[42]