Evidence-Based Complementary and Alternative Medicine / 2023 / Article / Tab 2 / Review Article
Pharmacological Effects of Genistein on Cardiovascular Diseases Table 2 The effects of genistein on cardio toxicity.
Study Design Doses Route of administration Effects Ref Adult rat ventricular myocytes 20 microM Dietary intake ↓Glucose toxicity-induced cardiac mechanical dysfunction [38 ] Guinea pig model — Chronic: daily subcutaneous injection for 10 days Acute: intraperitoneal injection 1 hour before endotoxic shock ↑plasma nitrate concentration ↑cGMP ↓APD [39 ] Mice 5 mg/kg Injection ↓Expressions of IL-6, IL-8, TNF-α ↑Protein expressions of HO-1, Nrf-2, NQO1 ↓Apoptosis [40 ] Diabetic rats 300 mg/kg/day Administered po for 24 weeks ↓Blood glucose ↓HbA1c ↓C-reactive protein ↓Expression of TNF-α ↓TGF-β 1 proteins ↑Total antioxidant [41 ] Mice (0.25, 0.5 or 1 mg/kg) intraperitoneal injection ↓Burn-induced myocardial injury ↑LVEF ↓Lactate dehydrogenase ↓level of creatine kinase ↓Apoptosis ↓Inducible NO synthase ↓NO and superoxide anions production ↑Expression of Hes1 and NICD1 ↓Burn-induced myocardial injury ↓Oxidative/nitrative stress [42 ]