Effects of a Macroporous Resin Extract of <i>Dendrobium officinale</i> Leaves in Rats with Hyperuricemia Induced by Anthropomorphic Unhealthy Lifestyle

<div>Effect of DoMRE on histopathological changes in the renal and intestine. (a) Renal tissues were stained with H&amp;E at a magnification of 200x: (A) glomerulus significantly atrophy; (B) glomerular rupture; (C) the renal tubules swollen and deformed. (b) The duodenum, ileum, and colon were stained with H&amp;E staining to observe crypt (A) and villus (B) at 200x. (c–h) The villus height (V), crypt depth (C), and V/C ratio in duodenum and ileum. IOD: integrated optical density; NC: normal control group; MC: model control group; DoMRE-L: low dose of DoMRE group; DoMRE-H: high dose of DoMRE group. The data were expressed as mean ± SD of 8 rats in each group. <sup>#</sup><span class="nowrap"><svg height="9.2729pt" id="M37" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.6359 44.8393 9.2729" width="44.8393pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.658,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.921,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,29.161,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,32.125,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,38.365,0)"><path d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z"></path></g></svg>;</span> <sup>##</sup><span class="nowrap"><svg height="9.2729pt" id="M38" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.6359 44.8393 9.2729" width="44.8393pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.658,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.921,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,29.161,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,32.125,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,38.365,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>,</span> compared with NC group; <span class="nowrap"><svg height="13.6833pt" id="M39" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -13.0463 49.9916 13.6833" width="49.9916pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0065,0,0,-0.0065,0,-9.852)"><path d="M503 164C503 183 495 209 482 228C429 236 402 243 352 269C402 295 428 304 482 311C494 330 503 355 502 376C485 385 459 391 436 390C403 347 383 328 336 298C338 354 343 381 365 431C353 451 337 471 318 481C302 471 283 451 273 431C293 381 300 354 303 298C255 328 235 346 202 389C179 390 153 385 135 374C135 355 143 329 156 310C210 302 236 295 286 269C236 243 210 234 156 227C144 208 135 183 136 162C153 153 180 147 202 148C235 191 255 210 303 240C300 184 295 157 274 107C285 87 301 67 320 57C337 67 355 87 365 107C345 157 339 184 336 240C383 210 404 192 436 149C460 148 485 153 503 164Z"></path></g><g transform="matrix(.013,0,0,-0.013,5.152,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g><g 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96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z"></path></g></svg>;</span> <span class="nowrap"><svg height="13.6833pt" id="M40" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -13.0463 54.1476 13.6833" width="54.1476pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0065,0,0,-0.0065,0,-9.852)"><path d="M503 164C503 183 495 209 482 228C429 236 402 243 352 269C402 295 428 304 482 311C494 330 503 355 502 376C485 385 459 391 436 390C403 347 383 328 336 298C338 354 343 381 365 431C353 451 337 471 318 481C302 471 283 451 273 431C293 381 300 354 303 298C255 328 235 346 202 389C179 390 153 385 135 374C135 355 143 329 156 310C210 302 236 295 286 269C236 243 210 234 156 227C144 208 135 183 136 162C153 153 180 147 202 148C235 191 255 210 303 240C300 184 295 157 274 107C285 87 301 67 320 57C337 67 355 87 365 107C345 157 339 184 336 240C383 210 404 192 436 149C460 148 485 153 503 164Z"></path></g><g transform="matrix(.0065,0,0,-0.0065,4.14,-9.852)"><path d="M503 164C503 183 495 209 482 228C429 236 402 243 352 269C402 295 428 304 482 311C494 330 503 355 502 376C485 385 459 391 436 390C403 347 383 328 336 298C338 354 343 381 365 431C353 451 337 471 318 481C302 471 283 451 273 431C293 381 300 354 303 298C255 328 235 346 202 389C179 390 153 385 135 374C135 355 143 329 156 310C210 302 236 295 286 269C236 243 210 234 156 227C144 208 135 183 136 162C153 153 180 147 202 148C235 191 255 210 303 240C300 184 295 157 274 107C285 87 301 67 320 57C337 67 355 87 365 107C345 157 339 184 336 240C383 210 404 192 436 149C460 148 485 153 503 164Z"></path></g><g transform="matrix(.013,0,0,-0.013,9.308,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g><g transform="matrix(.013,0,0,-0.013,20.966,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z"></path></g><g transform="matrix(.013,0,0,-0.013,32.229,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,38.469,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,41.433,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g 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Evidence-Based Complementary and Alternative Medicine

fig5

Figure 5

Figure 5: Effects of a Macroporous Resin Extract of <i>Dendrobium officinale</i> Leaves in Rats with Hyperuricemia Induced by Anthropomorphic Unhealthy Lifestyle 

Figure 5 | Effects of a Macroporous Resin Extract of Dendrobium officinale Leaves in Rats with Hyperuricemia Induced by Anthropomorphic Unhealthy Lifestyle 