Evidence-Based Complementary and Alternative Medicine

Medicinal Plants and Natural Active Compounds for Diabetes and/or Obesity Treatment


Publishing date
09 Oct 2015
Status
Published
Submission deadline
22 May 2015

Lead Editor

1Arab American University and Al-Qasemi Research Center, Baka El-Garbiah, Israel

2Al-Qasemi Academic College, Baka El-Garbiah, Israel

3King George’s Medical University, Lucknow, India

4Central Drug Research Institute, Lucknow, India

5University of Montreal, Montreal, Canada

6University of Jordan, Amman, Jordan


Medicinal Plants and Natural Active Compounds for Diabetes and/or Obesity Treatment

Description

Overweight and obesity are major risk factors for a number of chronic diseases, especially type 2 diabetes (T2D), leading to increase in healthcare costs and decrease in life expectancy. The incidence of obesity and T2D is in continuing rise. According to the World Health Organization (WHO), 35% of adults aged 20 and over were overweight in 2008, and 11% were obese. Moreover, T2D prevalence has increased from less than 10% in 1980 to more than 30% nowadays. Free fatty acids (FFA) represent a crucial link between obesity, inflammation, and insulin resistance and, as such, reduction in elevated plasma FFA should be an important therapeutic target in obesity and T2D.

There are several types of glucose-lowering drugs including insulin sensitizers, insulin secretagogues, and α-glucosidase inhibitors. Most glucose-lowering drugs, however, have side effects, such as severe hypoglycemia, idiosyncratic liver cell injury, lactic acidosis, permanent neurological deficit, digestive discomfort, headache, and dizziness. Hence, it is crucial to search for new drugs that would potentially have no or less side effects. Medicinal plant drug discovery provides important leads against various pharmacological targets. A large number of plants used in the traditional medicine have now become a part of the modern world healthcare system. Natural novel drugs are now more achievable due to modern techniques for separation, structure elucidation, screening, and bio- and chemoinformatics.

We invite investigators to contribute overview and original research articles dealing with the physiological as well as molecular and biochemical efficacy of medicinal plants and natural active compounds in treating T2D and obesity in vitro and in vivo. We are interested in articles that explore aspects of medicinal plants and their active compounds in obesity treatment, in insulin sensitizing, and particularly in the research of new targets for insulin sensitizers.

Potential topics include, but are not limited to:

  • Isolation and characterization of novel medicinal plants active compounds possessing antidiabetic and antiobesity potential benefits
  • Recent advances in drug discovery from medicinal plants with antidiabetic and antiobesity potentials
  • Identification and validation of novel targets of medicinal plants and active compounds insulin sensitizer, as well as studies of related fat metabolism
  • Identification of the cellular target of the effective antidiabetic plant extract(s), for example, proteins involved in the insulin action pathway
  • Medicinal plants with proven anti-inflammatory, antidiabetic, and weight loss benefits in human and animal models

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 469762
  • - Editorial

Medicinal Plants and Natural Active Compounds for Diabetes and/or Obesity Treatment

Hilal Zaid | Bashar Saad | ... | Fatma U. Afifi
  • Special Issue
  • - Volume 2015
  • - Article ID 651734
  • - Research Article

Bai-Hu-Jia-Ren-Shen-Tang Decoction Reduces Fatty Liver by Activating AMP-Activated Protein Kinase In Vitro and In Vivo

Hui-Kang Liu | Tzu-Min Hung | ... | Cheng Huang
  • Special Issue
  • - Volume 2015
  • - Article ID 492458
  • - Research Article

Adipogenic Activity of Wild Populations of Rhododendron groenlandicum, a Medicinal Shrub from the James Bay Cree Traditional Pharmacopeia

Michel Rapinski | Lina Musallam | ... | Alain Cuerrier
  • Special Issue
  • - Volume 2015
  • - Article ID 859048
  • - Research Article

Oxidative Stress Type Influences the Properties of Antioxidants Containing Polyphenols in RINm5F Beta Cells

Nathalie Auberval | Stéphanie Dal | ... | Séverine Sigrist
  • Special Issue
  • - Volume 2015
  • - Article ID 987385
  • - Research Article

Buckwheat Honey Attenuates Carbon Tetrachloride-Induced Liver and DNA Damage in Mice

Ni Cheng | Liming Wu | ... | Wei Cao
  • Special Issue
  • - Volume 2015
  • - Article ID 687690
  • - Research Article

Effects of Soothing Liver and Invigorating Spleen Recipes on the IKK-NF-B Signaling Pathway in Kupffer Cells of Nonalcoholic Steatohepatitis Rats

Xiang-Wen Gong | Yong-Jian Xu | ... | Yuan-Yuan Li
  • Special Issue
  • - Volume 2015
  • - Article ID 165457
  • - Research Article

Antioxidant and Anti-Inflammatory Activity Determination of One Hundred Kinds of Pure Chemical Compounds Using Offline and Online Screening HPLC Assay

Kwang Jin Lee | You Chang Oh | ... | Jin Yeul Ma
  • Special Issue
  • - Volume 2015
  • - Article ID 501272
  • - Research Article

Erchen Decoction Prevents High-Fat Diet Induced Metabolic Disorders in C57BL/6 Mice

Bi-Zhen Gao | Ji-Cheng Chen | ... | Shan-Shan Ding
  • Special Issue
  • - Volume 2015
  • - Article ID 980345
  • - Research Article

Deepure Tea Improves High Fat Diet-Induced Insulin Resistance and Nonalcoholic Fatty Liver Disease

Jing-Na Deng | Juan Li | ... | Jing-Yan Han
  • Special Issue
  • - Volume 2015
  • - Article ID 385976
  • - Research Article

Blackcurrant Suppresses Metabolic Syndrome Induced by High-Fructose Diet in Rats

Ji Hun Park | Min Chul Kho | ... | Ho Sub Lee
Evidence-Based Complementary and Alternative Medicine
 Journal metrics
Acceptance rate28%
Submission to final decision80 days
Acceptance to publication46 days
CiteScore2.010
Impact Factor1.984
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