Evidence-Based Complementary and Alternative Medicine

Mechanistic Roles of Plant Secondary Metabolites in Oxidative Stress-Linked Diseases


Publishing date
01 Mar 2021
Status
Closed
Submission deadline
06 Nov 2020

Lead Editor

1Durban University of Technology, Durban, South Africa

2Agricultural Research Council, Pretoria, South Africa

3Nile University, Abuja, Nigeria

This issue is now closed for submissions.
More articles will be published in the near future.

Mechanistic Roles of Plant Secondary Metabolites in Oxidative Stress-Linked Diseases

This issue is now closed for submissions.
More articles will be published in the near future.

Description

The concept of phytopharmacology is perhaps the most assorted of all therapeutic systems. Throughout the last few decades, it has become evident that there exists a plethora of plants with pharmacological potential and it is increasingly being accepted that phytotherapy could offer potential lead compounds in the drug discovery/development process. The interest in phytotherapy could be attributed to secondary metabolites that may act individually, additively, or in synergy to improve health. Indeed, medicinal plants, unlike pharmacological drugs, commonly have bioactive constituents working together catalytically and synergistically to produce a combined effect that surpasses the total activity of the individual constituents. The combined actions of these substances tend to increase the activity of the main constituent by speeding up or slowing down its assimilation into the body. In addition, the secondary metabolites might increase the stability of the active phytonutrients, minimize the rate of undesired adverse effects, and have an additive, potentiating, or antagonistic effect. In spite of their perceived roles, studies reporting their exact mechanism of action in oxidative stress-linked disorders like diabetes, cancer, neurodegenerative disorders, nephrotoxicity, and hepatotoxicity are limited and poorly appraised.

In view of this, the concept of a ‘mechanistic approach’ (evidence-based molecular studies, detailed structural and functional characterization, structure based molecular docking/dynamics, etc.) is currently being explored, and could find relevance and may provide useful data supporting the efficacy of phytotherapies. Ultimately, this will serve as a significant panacea for issues against the advancement of phytopharmacology. Studies in this niche hold promising scope for discovering new and novel therapeutic products of medical importance.

This Special Issue aims to collate original research articles that seek to provide an evidence-based mechanistic approach to the study of complementary and alternative medicine and invites submissions detailing the characterization and biological mechanisms of action of plant secondary metabolites in diseases associated with oxidative stress, while reporting health benefits. Novel review articles appraising the purview of the mechanism of action of plant secondary metabolites in the management of degenerative diseases are also welcome.

Potential topics include but are not limited to the following:

  • Mechanistic role of plant secondary metabolites in the management of diabetes and obesity, hepatotoxicity, nephrotoxicity, peptic ulcers, etc.
  • Evidence of plant secondary metabolites effectiveness as an antioxidant through clinical experimentation, and in vitro and in vivo experimental models
  • An understanding of the underlying factors and oxidative stress involvement in degenerative disorders
  • Analytical approach to characterize and analyse plant secondary metabolites for absorption, distribution, metabolism, and excretion toxicity (ADMET)
  • Credence to the in vitro, in silico and in vivo mechanistic role of mitocans and other plant metabolites in cancer therapy

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 8810368
  • - Research Article

Botanical from Piper capense Fruit Can Help to Combat the Melanoma as Demonstrated by In Vitro and In Vivo Studies

Brice E. N. Wamba | Paramita Ghosh | ... | Nabendu Murmu
  • Special Issue
  • - Volume 2020
  • - Article ID 6669813
  • - Research Article

Therapeutic and Preventive Effects of Olea europaea Extract on Indomethacin-Induced Small Intestinal Injury Model in Rats

Fatemeh Sadat Mahdavi | Parham Mardi | ... | Mahboobeh Mehrabani-Natanzi
  • Special Issue
  • - Volume 2020
  • - Article ID 4314807
  • - Research Article

Cytotoxic Constituents of the Bark of Hypericum roeperianum towards Multidrug-Resistant Cancer Cells

Michel-Gael F. Guefack | Francois Damen | ... | Victor Kuete
  • Special Issue
  • - Volume 2020
  • - Article ID 9529042
  • - Research Article

In Vitro Antioxidant and Antidiabetic Potentials of Syzygium caryophyllatum L. Alston

Herath Pathiranage Thathmi Wathsara | Hasitha Dhananjaya Weeratunge | ... | Pathmasiri Ranasinghe
  • Special Issue
  • - Volume 2020
  • - Article ID 7815348
  • - Research Article

Aqueous Root Bark Extract of Daniellia oliveri (Hutch. & Dalz.) (Fabaceae) Protects Neurons against Diazepam-Induced Amnesia in Mice

Galba Jean Beppe | Lea Blondelle Kenko Djoumessie | ... | Harquin Simplice Foyet
  • Special Issue
  • - Volume 2020
  • - Article ID 7956493
  • - Research Article

Effect of Cellgevity® Supplement on Selected Rat Liver Cytochrome P450 Enzyme Activity and Pharmacokinetic Parameters of Carbamazepine

Seth Kwabena Amponsah | Benoit Banga N’guessan | ... | Regina Appiah-Opong
Evidence-Based Complementary and Alternative Medicine
 Journal metrics
Acceptance rate27%
Submission to final decision68 days
Acceptance to publication33 days
CiteScore3.000
Journal Citation Indicator0.730
Impact Factor2.629
 Submit

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.