Pain is a common condition in humans. Because of this, conventional therapies are losing their effectiveness, increasing the need for new molecules and alternative therapies. Pharmacological studies have demonstrated that products of natural origin are promising for the development of new molecules or therapies, especially for pain management. Several drugs used today have emerged from the isolation and identification of biologically active compounds and molecules in nature, prompting the improvement of the health and pharmaceutical sectors. In this sense, there is considerable interest in identifying new therapeutic agents obtained from plants used in popular medicine.

One of the reasons for this interest is that the drugs currently available have a number of adverse effects, and new strategies are needed to improve treatment. However, we cannot ignore that many of these plants are used without any scientific evidence to demonstrate their effectiveness and safety. Thus, the most effective, low cost, safe, and readily available new drugs and therapies may be developed through comprehensive investigation of the bioactivity of several natural compounds.

The aim of this Special Issue is to compile original research and reviews that address new natural products with analgesic properties. Studies interested in detecting the mechanism of action of new molecules, as well as those that show toxic effects of treating pain with natural products, are welcome.

Potential topics include but are not limited to the following:

• Effects of new medicinal plants in pain management (in vitro or in vivo tests)
• Safety and/or adverse effects of medicinal plants with analgesic activities
• The isolation of new analgesic molecules of natural products
• Comparison of analgesic effects between natural and synthetic compounds
• Systematic review and/or meta-analysis of the use of medicinal plants for pain management based on a specific regions or communities
• The mode of action of plants with analgesic activities
• Effects of new medicinal plants with analgesic properties using animal models of chronic pain
• Herbal medicinal products for neuropathic pain