Evidence-Based Complementary and Alternative Medicine

Complementary and Alternative Medicine in Cancer Stem Cells


Publishing date
14 Jun 2013
Status
Published
Submission deadline
25 Jan 2013

Lead Editor

1Department of Biochemical Science and Technology, National Chiayi University, Chiayi 600, Taiwan

2Department of Radiation Oncology, Columbia University, New York, NY 10032, USA

3Department of Medical Research and Department of Radiation Oncology, Mackay Memorial Hospital, Taipei 104, Taiwan

4Department of Ophthalmology and Visual Sciences, Vanderbilt University, Nashville, TN 37232, USA


Complementary and Alternative Medicine in Cancer Stem Cells

Description

Cancer stem cells (CSCs) resemble normal stem cells with self-renewal and differentiation characteristics. CSCs have been detected within cancers that may form tumorigenesis from a small subpopulation of cells. CSCs have recently been identified in leukemia and solid tumors, including melanoma, multiple myeloma, brain, breast, colon, ovary, pancreas, and prostate cancers. There is growing evidence indicating that CSCs are principal players to the development of resistance to cancer treatments including chemotherapy and radiotherapy. This is clinically significant since resistant CSCs may lead to relapse and distant metastasis and give rise to new tumors. Emerging data indicates that CSCs and normal stem cells may share cellular pathways regulating proliferation and differentiation. These pathways include, but not limited to, polycomb group transcriptional repressor Bmi-1, Notch, Sonic hedgehog, and Wnt pathways. Therefore, identification of CSC markers, selection and development of unique therapeutics targeting CSCs, and mechanisms regulating of molecular expression of CSCs phenotype which prevent recurrence or metastasis will provide insight to novel intervention strategies for future cancer treatments. We invite experts to contribute original research and review articles that explore aspects of complementary and alternative medicine (CAM) that associated with CSCs in basic research, in translational medicine, and in clinical application for cancer treatment.

The topic will highlight current research, encourage additional research, draw attention to the subject, and ultimately help advance the field of CAM application in CSCs. All the articles need to be related to the area of CAM. Potential topics include, but are not limited to:

  • Screening platform establishment for effective agents acting on CSCs
  • Development of agents modulating CSC signaling pathways
  • Overcoming treatment resistance related to CSCs
  • Influencing of microenvironment on CSCs
  • Targeting therapeutics and accompanying biomarkers on CSCs
  • Translational research on CAM treatment and CSCs
  • Chemical modification, formulation, optimization, and pharmacokinetics/pharmacodynamics of CAM related to management of CSCs
  • Recent advances in drug development from CAM related to CSCs
  • Genetic approaches to personalized medicine related to CAM and CSCs
  • Evaluation of the advantage and disadvantage in CSC aspect of conventional cancer treatment with and without the combination of CAM

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ecam/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/ecam/cstem/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 560274
  • - Editorial

Complementary and Alternative Medicine in Cancer Stem Cells

Hui-Fen Liao | K. S. Clifford Chao | ... | Min Shen Chang
  • Special Issue
  • - Volume 2013
  • - Article ID 258425
  • - Research Article

BlueBerry Isolate, Pterostilbene, Functions as a Potential Anticancer Stem Cell Agent in Suppressing Irradiation-Mediated Enrichment of Hepatoma Stem Cells

Chi-Ming Lee | Yen-Hao Su | ... | Chi-Tai Yeh
  • Special Issue
  • - Volume 2013
  • - Article ID 910451
  • - Research Article

A Preclinical Evaluation of Antimycin A as a Potential Antilung Cancer Stem Cell Agent

Chi-Tai Yeh | Chun-Li Su | ... | Alexander T. H. Wu
  • Special Issue
  • - Volume 2013
  • - Article ID 946451
  • - Research Article

Active Component of Antrodia cinnamomea Mycelia Targeting Head and Neck Cancer Initiating Cells through Exaggerated Autophagic Cell Death

Ching-Wen Chang | Chien-Chih Chen | ... | Jeng-Fan Lo
  • Special Issue
  • - Volume 2013
  • - Article ID 632121
  • - Research Article

Resveratrol Inhibits Alpha-Melanocyte-Stimulating Hormone Signaling, Viability, and Invasiveness in Melanoma Cells

Yu-Jen Chen | Ying-Yin Chen | ... | Hui-Fen Liao
  • Special Issue
  • - Volume 2013
  • - Article ID 748587
  • - Review Article

Targeting Sonic Hedgehog Signaling by Compounds and Derivatives from Natural Products

Yu-Chuen Huang | K. S. Clifford Chao | ... | Yu-Jen Chen
  • Special Issue
  • - Volume 2013
  • - Article ID 590393
  • - Research Article

Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation

Yao-An Shen | Chien-Hung Lin | ... | Yann-Jang Chen
  • Special Issue
  • - Volume 2013
  • - Article ID 268468
  • - Research Article

β-Elemene-Attenuated Tumor Angiogenesis by Targeting Notch-1 in Gastric Cancer Stem-Like Cells

Bing Yan | Yuqi Zhou | ... | Zhifeng Qin
  • Special Issue
  • - Volume 2013
  • - Article ID 170261
  • - Research Article

Cyclohexylmethyl Flavonoids Suppress Propagation of Breast Cancer Stem Cells via Downregulation of NANOG

Wen-Ying Liao | Chih-Chuang Liaw | ... | Chia-Ning Shen
  • Special Issue
  • - Volume 2013
  • - Article ID 569737
  • - Research Article

Medicinal Fungus Antrodia cinnamomea Inhibits Growth and Cancer Stem Cell Characteristics of Hepatocellular Carcinoma

Yu-Ming Liu | Yu-Kuo Liu | ... | Yu-Jen Chen
Evidence-Based Complementary and Alternative Medicine
 Journal metrics
Acceptance rate28%
Submission to final decision72 days
Acceptance to publication43 days
CiteScore2.010
Impact Factor1.984
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