Evidence-Based Complementary and Alternative Medicine

Natural Products and Tissue Repair: Identification, Relevance and Applicability


Publishing date
01 Jan 2021
Status
Closed
Submission deadline
14 Aug 2020

1Federal University of Viçosa, Viçosa, Brazil

2Federal University of Alfenas, Alfenas, Brazil

3University of Lagos, Lagos, Nigeria

This issue is now closed for submissions.
More articles will be published in the near future.

Natural Products and Tissue Repair: Identification, Relevance and Applicability

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Tissue repair is a process that involves a complex interaction between cells, extracellular matrix, blood vessels and tissue growth factors. This process is organized into four phases: hemostasis, inflammation, proliferation and tissue remodeling. Initially, the formation of a platelet plug and activation of the coagulation cascade controls bleeding at the site of injury. In the inflammatory phase, massive leucocytes influx into the wound area, which reinforces antimicrobial defenses and triggers the synthesis of pro- and anti-inflammatory effectors (i.e. cytokines and grown factors) that are responsible for the subsequent steps of tissue repair. Guided by molecules, such as: PDGF, FGF and TGF-β, the next phase (proliferative stage), characterized by intense cell proliferation and secretion of a provisory extra cellular matrix (ECM), covers the injured area with highly vascularized and hydrated tissue. Following this, apoptosis of leukocytes, down-regulation of pro-inflammatory mediators and increase of anti-inflammatory mediators that conduces to a remodeling process, results in tissue regeneration or healing. In regenerative processes, the newly formed tissue gradually acquires similar morphofunctional characteristics typically observed in uninjured tissues. Conversely, a different tissue develops from the healing process which exhibits divergent morphofunctional characteristics compared to the original tissue.

Due to the complexity and interdependence of all phases of tissue repair, morphofunctional disturbances are not uncommon, especially when associated to metabolic (i.e. diabetes mellitus and vasculopathies) and microbial diseases (i.e. bacterial, fungal and parasitic infections). Currently, there is an increasing interest in biotechnological and pharmacological development of more effective approaches to treat different types of injuries in target organs. In regenerative medicine, natural products derived from plants, animals, minerals and microorganisms have been considered as a rich source of bioactive molecules with potential relevance and applicability in direct or complementary strategies focused on tissue repair. Thus, several natural products with immunomodulatory, pro-angiogenic and antimicrobial properties, as well as cell proliferation inducers, have been successfully identified, providing a rational basis that supports their research and development platforms directed to the construction of new products with direct application in regenerative medicine.

This Special Issue aims to create an interdisciplinary platform involving morphological, physiological, biochemical, molecular, pathological and biotechnological issues to discuss the identification, relevance and applicability of natural products in the repair of tissue and organ injuries. In addition, we aim to identify the importance of the ethnopharmacological approach in the search for natural products for tissue repair, and to analyze the toxicology and contraindications of natural products for tissue repair. We welcome original research articles (in silico, in vitro and in vivo) and review articles that will illustrate and stimulate the continuing effort to understand the effect of naturals compounds in the tissue repair.

Potential topics include but are not limited to the following:

  • Identification of natural products applicable to regenerative medicine
  • Development of healing products based on natural products
  • Combination of natural and synthetic healing products
  • Regenerative mechanisms of natural products
  • Analytical methods and instrumentation applied to the evaluation of the healing effects of natural products.
  • Ethnopharmacology approach in the search for natural products for tissue repair
  • Comparison between synthetic drugs and natural products for tissue repair
  • Toxicology and contraindications of natural products for tissue repair

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 3054521
  • - Research Article

Antioxidant and Anti-Inflammatory Effects of Anacardium occidentale L. and Anacardium microcarpum D. Extracts on the Liver of IL-10 Knockout Mice

Anderson Barbosa Baptista | Mariáurea M. Sarandy | ... | Maria do Carmo Gouveia Peluzio
  • Special Issue
  • - Volume 2020
  • - Article ID 3708730
  • - Research Article

The Preventive Effects of Asparagus officinalis Extract on Sodium Selenite-Induced Cataractogenesis in Experimental Animal Models

Momammad Azadbakht | Mohammad Asghari | ... | Amirhossein Ahmadi
  • Special Issue
  • - Volume 2020
  • - Article ID 3236768
  • - Research Article

Revealing the Pharmacological Mechanism of Acorus tatarinowii in the Treatment of Ischemic Stroke Based on Network Pharmacology

FengZhi Liu | Qian Zhao | ... | Lingqun Zhu
  • Special Issue
  • - Volume 2020
  • - Article ID 3106076
  • - Research Article

Traditional Chinese Medicine Formulation Huangqi Jianzhong Tang Improves Cardiac Function after Myocardial Infarction in Rats

Ya-Ru Bao | Wen-Yi Jiang | ... | Guo-Xing Zhang
  • Special Issue
  • - Volume 2020
  • - Article ID 5754823
  • - Research Article

Meta-Analysis of the Therapeutic Effect of Shenqi Jiangtang Granule on Type 2 Diabetes Mellitus

Ruo-Lan Li | Tai-Wei Dong | ... | Miao-Miao Xi
  • Special Issue
  • - Volume 2020
  • - Article ID 8858291
  • - Research Article

In Vitro and In Vivo Wound Healing and Anti-Inflammatory Activities of Babassu Oil (Attalea speciosa Mart. Ex Spreng., Arecaceae)

José Alex A. Santos | José Wellinton da Silva | ... | Rafael M. Ximenes
  • Special Issue
  • - Volume 2020
  • - Article ID 2407239
  • - Research Article

Effect of Total Flavonoids of Oxytropis falcata Bunge on the Expression of p-JAK1-and p-STAT1-Related Proteins in Idiopathic Pulmonary Fibrosis

Yan-jun Wang | Yang Li | ... | Hai-xia Ming
  • Special Issue
  • - Volume 2020
  • - Article ID 7525713
  • - Review Article

Allopathic and Naturopathic Medicine and Their Objective Consideration of Congruent Pursuit

Ivan Uher | Jaroslaw Cholewa | ... | Mária Jusková
  • Special Issue
  • - Volume 2020
  • - Article ID 1403572
  • - Research Article

In Vitro Evaluation of the Neuroprotective Effect of Panax notoginseng Saponins by Activating the EGFR/PI3K/AKT Pathway

Shuang Wu | Tiantian Yang | ... | Lingqun Zhu
  • Special Issue
  • - Volume 2020
  • - Article ID 8273986
  • - Research Article

Acidic Phospholipase A2-Peptide Derivative Modulates Oxidative Status and Microstructural Reorganization of Scar Tissue after Cutaneous Injury

Estefanny Ruiz García | Edvaldo Barros | ... | Reggiani Vilela Gonçalves
Evidence-Based Complementary and Alternative Medicine
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