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Plants as Source of Promising Lead Compounds for the Development of Therapeutic Agents against Multidrug-Resistance

Call for Papers

Even though the number of drugs currently used in clinical practice of infectious diseases and oncology is high, the development of resistance necessitates the discovery of new effective agents. Plants have been an endless source of compounds with great structural diversity showing various modes of action against resistant bacteria and cancer cells. The enormous potential of plants for providing new and active chemical entities encourages scientists to continue searching for them. These structures will enrich natural product libraries to be used for the discovery of lead compounds and the development of drug candidates for successful chemotherapy against resistant phenotypes.

This special issue intends to collect cutting-edge research and review works illustrating the potential of natural products against multidrug resistance and brings together organic chemists, pharmacognosists, pharmacologists, toxicologists, biologists, artificial intelligence experts, computer-aided drug design scientists, and clinicians working as a multidisciplinary team in the area of natural products.

We do hope that this special issue will provide extensive and applied knowledge to stimulate interest of scientists to contribute to finding new avenues to develop potential therapeutic agents of natural origin against multidrug resistant (MDR) bacteria and cancer.

Potential topics include but are not limited to the following:

  • Identification of compounds obtained from plants with inhibitory activity against multidrug-resistant (MDR) bacteria and/or cancer
  • In vitro screening of an important number of plant extracts with inhibitory activity against MDR bacteria and/or cancer
  • In vivo models for testing plant-derived products with inhibitory activity against MDR bacteria and/or cancer
  • Mechanisms of action of plant-derived compounds active against bacteria and cancer cells with MDR phenotypes
  • Computer-Aided Drug Design (CADD) as virtual tool for screening and prediction of bioactive compounds against MDR bacteria and/or cancer
  • Evaluation of synergy among bioactive chemical compounds (plant-derived or synthetic) against MDR cells
  • Synthetic derivatives of natural products active against MDR phenotypes for structure activity relationship studies (SARS)

Authors can submit their manuscripts through the Manuscript Tracking System at

Submission DeadlineFriday, 27 July 2018
Publication DateDecember 2018

Papers are published upon acceptance, regardless of the Special Issue publication date.

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