From ancient time, humanity has been treating various ailments with medicinal plants. Enzymes are powerful natural catalysts for each biochemical process in nature. Some cultures believe that specific foods composed of unique components of bitter greens such as glucosinolates have the potential to combat cancer. The Allium family as well as the mustard seeds, horseradish roots, and cress and rocket leaves are also considered as cancer-fighting foods. In concert with the anticancer effects, some medicinal plants have antiaging potential due to their antioxidants. The presence of appropriate levels of enzyme is crucial in maintaining a healthy body system. However, overexpression of enzymes may lead to an abnormal cascade of biological events which ultimately result in disease. Even though several natural inhibitors in the medicinal plant kingdom exist, there is a safety issue in their use due to their associations with other undesired molecules which have not been fully elucidated. Therefore, even though medicinal plants have vast potential for cure and management of various diseases, the challenge remains to determine specific components of specific pharmacological activity and also to establish their safety.

We invite investigators to contribute original research articles as well as reviews that provide solid evidence to support/oppose the application of complementary and alternative medicines (CAM) in the management/treatment of various diseases. We are particularly interested in articles reporting randomized, double blind, and placebo-controlled trials or revealing the action mechanisms of CAM by using different (in vitro as well as in vivo) models focusing on enzyme inhibition strategy. Potential topics include, but are not limited to:

• Current research updates on enzyme interaction from medicinal plants in management of various disorders
• Optimization of multiherb prescriptions in treating aging disorders based on enzyme studies
• Clinical trials of CAM on prophylactic and/or therapeutic treatments of neurodegenerative disorders via targeting specific enzymes
• Recent applications of CAM in management of cancer by enzymes inhibition
• Advances in revealing target enzymes for CAM in treating type 2 diabetes mellitus
• Synergistic inhibitory actions of enzyme constituents derived from medicinal herbs

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