Evidence-Based Complementary and Alternative Medicine

Natural Bioactive Ingredients as Oxidative Medicines with Antimicrobial Activity for Chronic Disease Treatment: from Drug Development to Industrial Production


Publishing date
01 Jan 2022
Status
Closed
Submission deadline
10 Sep 2021

Lead Editor

1Central South University, Changsha, China

2Monash University, Melbourne, Australia

This issue is now closed for submissions.

Natural Bioactive Ingredients as Oxidative Medicines with Antimicrobial Activity for Chronic Disease Treatment: from Drug Development to Industrial Production

This issue is now closed for submissions.

Description

Recently, natural bioactive ingredients of oxidative medicines have been a focus of many studies owing to their low toxicity and side effects as well as their excellent efficacy. Bioactive ingredients are the main components extracted from herbs that have therapeutic properties. Bioactive ingredients have multilevel effects on numerous chronic diseases, such as the treatment of asthma, anti-inflammation, anti-infection, antimicrobial activity, and the treatment of diabetes mellitus. Usually, the bioactive ingredients of conventional oxidative medicines have been divided into six categories consisting of flavonoids, saponins, terpenoids, alkaloids, polysaccharides, and other organic acids. In addition, studies found that curcumin, magnolol, animal protein, photosensitizers, and reactive oxide species with antimicrobial activity have positive effects in chronic disease treatment. Especially, active polyphenol curcumin as a pro-drug via oxidative activation into reactive metabolites showed excellent anti-inflammatory activities and antibacterial activities.

Although considerable efforts have been made to apply these bioactive ingredients to chronic disease treatment, the lack of systematic studies on therapeutic mechanisms of these bioactive ingredients for disease treatment impedes the extensive application of these oxidative medicines in vivo. For example, the bioactivation of curcumin will occur in vitro, while bioactivation is insufficient in vivo. Therefore, the evaluation and design of clinical trials of curcumin and other medicinal polyphenols should be considered. In addition, the functional mechanism of bioactive ingredients must be highlighted in future research. The safety evaluation and bioavailability of bioactive ingredients are also important indexes for the development of oxidative medicines. The physicochemical and biological properties of curcumin and other bioactive ingredients should also be further discussed before their clinical usage. Furthermore, the industrial production of natural bioactive ingredients is still a huge challenge at present.

This Special Issue aims to summarize the knowledge of underlying mechanisms and physicochemical properties of bioactive ingredients in chronic disease treatment and provide a fully integrated, reliable source of information for the clinical application of bioactive ingredients as oxidative medicines. Original research and review articles are welcome.

Potential topics include but are not limited to the following:

  • Therapeutic properties of natural bioactive ingredients
  • Multilevel effects of bioactive ingredients on treatment of chronic disease
  • Application of bioactive ingredients
  • Safety evaluation of bioactive ingredients
  • Bioavailability of natural bioactive ingredients
  • Functional mechanism of bioactive ingredients for disease treatment
  • Synthesized methods and instrumental analysis of natural bioactive ingredients
  • Chemical engineering and industrial production

Articles

  • Special Issue
  • - Volume 2023
  • - Article ID 9873681
  • - Retraction

Retracted: Influence of Bushen Tiaochong Cycle Therapy on Th1/Th2 Deviation, Sex Hormone Level, and Pregnancy Outcome of Alloimmune Recurrent Spontaneous Abortion

Evidence-Based Complementary and Alternative Medicine
  • Special Issue
  • - Volume 2023
  • - Article ID 9862610
  • - Retraction

Retracted: A Clinical Study of the Effect of Estradiol Valerate on Sleep Disorders, Negative Emotions, and Quality of Life in Perimenopausal Women

Evidence-Based Complementary and Alternative Medicine
  • Special Issue
  • - Volume 2023
  • - Article ID 9872701
  • - Retraction

Retracted: Huayu Tongluo Recipe Attenuates Renal Oxidative Stress and Inflammation through the Activation of AMPK/Nrf2 Signaling Pathway in Streptozotocin- (STZ-) Induced Diabetic Rats

Evidence-Based Complementary and Alternative Medicine
  • Special Issue
  • - Volume 2023
  • - Article ID 9851029
  • - Retraction

Retracted: Effect of Anti-Infective Reconstituted Bone Xenograft Combined with External Fixator on Serum CRP and PCT Levels and Prognosis of Patients with Bone Infection after Lower Extremity Long Bone Trauma

Evidence-Based Complementary and Alternative Medicine
  • Special Issue
  • - Volume 2023
  • - Article ID 9757421
  • - Retraction

Retracted: Effect of Observation of Shou Hui Tong Bian Capsule (Polygonum Multiflorum and Aloe-Based Herbal Capsule for Cathartic Effect) in Rapid Rehabilitation of Joint Surgery

Evidence-Based Complementary and Alternative Medicine
  • Special Issue
  • - Volume 2023
  • - Article ID 9787136
  • - Retraction

Retracted: Effect of MiR-375 Regulates YAP1 on the Invasion, Apoptosis, and Epithelial-Mesenchymal Transition of Cervical Cancer HeLa Cells

Evidence-Based Complementary and Alternative Medicine
  • Special Issue
  • - Volume 2023
  • - Article ID 9762535
  • - Retraction

Retracted: Regulation of Apelin-13 on Bcl-2 and Caspase-3 and Its Effects on Adipocyte Apoptosis

Evidence-Based Complementary and Alternative Medicine
  • Special Issue
  • - Volume 2023
  • - Article ID 9756594
  • - Retraction

Retracted: Serum MMP-9 and SAA in the Diagnosis of Severe Pneumonia Caused by Radiotherapy of Esophageal Cancer

Evidence-Based Complementary and Alternative Medicine
  • Special Issue
  • - Volume 2023
  • - Article ID 9836367
  • - Retraction

Retracted: Proteomics Analysis of Serum Proteins in Gestational Diabetes

Evidence-Based Complementary and Alternative Medicine
  • Special Issue
  • - Volume 2023
  • - Article ID 9816503
  • - Retraction

Retracted: Predictive Value of MPV and Plasma NT-ProBNP Combined with the Simplified Geneva Scale for the Prognosis of Acute Pulmonary Embolism

Evidence-Based Complementary and Alternative Medicine
Evidence-Based Complementary and Alternative Medicine
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Acceptance rate7%
Submission to final decision145 days
Acceptance to publication29 days
CiteScore3.500
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