Oxidative stress is a severe imbalance between the development of reactive oxygen species, reactive nitrogen species, and antioxidant defenses. Numerous studies have demonstrated that oxidative stress contributes significantly to the pathogenesis and progression of different diseases, such as Alzheimer’s disease.

Flavonoids are an important class of natural products. They belong to a class of plant secondary metabolites with a polyphenolic structure, commonly found in fruits, vegetables, and some beverages. Biological activities include antioxidant, anti-cholinesterase, anti-inflammatory, antimicrobial, and disease-combating effects. Almost every flavonoid group has the capacity to function as antioxidants. They have numerous beneficial biochemical and antioxidant effects associated with various diseases such as cancer, Alzheimer's disease, atherosclerosis, etc. Flavonoids are associated with a wide variety of health-promoting effects and are an indispensable component.

The aim of this Special Issue is to solicit original research articles covering all aspects of the antioxidant activity of flavonoids in health and disease. Submissions focusing on elucidating their underlying mechanisms of action, especially with molecular approaches, are highly encouraged. Review articles discussing the state of the art are also welcome.

Potential topics include but are not limited to the following:

• Receptor-ligand molecular docking experiments to predict the affinity of flavonoids within the binding sites
• Pharmacological evaluation of flavonoids as antioxidants: in vitro and in vivo assays
• Impact of flavonoids as antioxidants on neuroinflammation and neurodegeneration
• Neurobehavioral pharmacological studies (e.g., using zebrafish or rodent models) to assess flavonoids as antioxidant agents in health and disease
• Receptor-ligand molecular docking experiment correlation with antioxidant, and anti-cholinesterase activities
• Impact of flavonoids as antioxidants on diabetes mellitus and their mechanism of action