Evidence-Based Complementary and Alternative Medicine

Natural Products as Sources of Antimalarial Drugs


Publishing date
01 Nov 2019
Status
Closed
Submission deadline
28 Jun 2019

Lead Editor

1University of Nigeria, Nsukka, Nigeria

2Atma Jaya University (UAJ), Jakarta, Indonesia

This issue is now closed for submissions.
More articles will be published in the near future.

Natural Products as Sources of Antimalarial Drugs

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Despite the advances in malarial chemotherapy, malaria remains a devastating disease in several parts of the world, particularly in sub-Saharan Africa. There is currently a great concern that the Plasmodium species will soon develop total resistance to existing antimalarial drugs due to recent reports of increasing resistance of the parasite to drugs, including the newly introduced artemisinin-based compounds, in many endemic areas. In addition, the mosquito vector has also developed resistance against the insecticides. Also, the high cost, along with the adverse effects associated with some of the existing drugs, limits their usefulness in malarial treatment. Given the above, there is currently an urgent need to search for novel and more efficacious drugs to combat the disease.

Natural products, including medicinal plants, have been used in the traditional treatment of malaria for thousands of years due to their efficacy, safety, lower cost, and availability. In fact, medicinal plants are the source of the two most successful antimalarial drugs, artemisinin and quinine. Studies into the antimalarial activity of natural products (extracts and compounds) derived from medicinal plants, animals, or micro-organisms therefore become quite expedient.

The aim of this special issue is to present important studies, both original research and review articles, on the investigation of the antimalarial potentials of natural product derived extracts or compounds. Articles on the use of herbs in combination with drugs for the treatment of malaria are also welcomed.

We invite investigators to submit original research articles and reviews to this special issue.

Potential topics include but are not limited to the following:

  • Antiplasmodial activity studies (in vitro or in vivo) of the extracts or compounds from plants, animals, or micro-organisms
  • The isolation of antimalarial principles of natural products
  • The mode of action of compounds or extracts having antiplasmodial activity
  • Adverse effect of antimalarial natural products
  • The in silico design of natural compounds with antiplasmodial activity
  • Novel formulations for delivery of antimalarial extracts or compounds from natural sources

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 8749083
  • - Review Article

Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies

Philip F. Uzor
  • Special Issue
  • - Volume 2019
  • - Article ID 7967980
  • - Research Article

In Vitro Antiplasmodium and Chloroquine Resistance Reversal Effects of Andrographolide

Zaid O. Ibraheem | Roslaini Abd Majid | ... | Rusliza Basir
  • Special Issue
  • - Volume 2019
  • - Article ID 7390385
  • - Research Article

Various Parts of Helianthus annuus Plants as New Sources of Antimalarial Drugs

Wiwied Ekasari | Dwi Widya Pratiwi | ... | Heny Arwati
  • Special Issue
  • - Volume 2019
  • - Article ID 6825297
  • - Research Article

Evaluation of the Bioactivities of Rumex crispus L. Leaves and Root Extracts Using Toxicity, Antimicrobial, and Antiparasitic Assays

Oladayo Amed Idris | Olubunmi Abosede Wintola | Anthony Jide Afolayan
  • Special Issue
  • - Volume 2019
  • - Article ID 3057180
  • - Review Article

Exploring Antimalarial Herbal Plants across Communities in Uganda Based on Electronic Data

Denis Okello | Youngmin Kang
  • Special Issue
  • - Volume 2019
  • - Article ID 5410923
  • - Research Article

Phytochemical Constituents, Antioxidant, Cytotoxicity, Antimicrobial, Antitrypanosomal, and Antimalarial Potentials of the Crude Extracts of Callistemon citrinus

Rotimi Larayetan | Zacchaeus S. Ololade | ... | Ayodele Ladokun
  • Special Issue
  • - Volume 2019
  • - Article ID 8324596
  • - Research Article

Antimalarial Activity of Cordia africana (Lam.) (Boraginaceae) Leaf Extracts and Solvent Fractions in Plasmodium berghei-Infected Mice

Dawit Zewdu Wondafrash | Dayananda Bhoumik | ... | Brhane Teklebrhan Assefa
Evidence-Based Complementary and Alternative Medicine
 Journal metrics
Acceptance rate28%
Submission to final decision76 days
Acceptance to publication44 days
CiteScore2.010
Impact Factor1.984
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