Evidence-Based Complementary and Alternative Medicine

New Discovery of Curcumin Combination Therapy and Action Mechanism


Publishing date
01 Nov 2019
Status
Closed
Submission deadline
21 Jun 2019

Lead Editor

1University of Texas Southwestern Medical Center, Dallas, USA

2Northeast Agricultural University, Harbin, China

3Chinese Academy of Agricultural Sciences, Shanghai, China

This issue is now closed for submissions.
More articles will be published in the near future.

New Discovery of Curcumin Combination Therapy and Action Mechanism

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Each drug or treatment method approved by the FDA must be proved of its effectiveness in the clinic. Due to the limitation of maximum dosages, resistances, or other factors, the therapeutic response with monotherapy may not always be as expected, whereas combination therapy may offer some advantages and improve clinical outcomes. Natural products are an important source of drug research for the future. A novel application of natural substances is combination therapy, which consists of the administration of two or more substances, such as conventional chemotherapeutics plus a natural compound, or multiple natural compounds at a time.

Curcumin (diferuloylmethane, a yellow pigment in spice turmeric) is a natural product polyphenol extracted from the rhizome of Curcuma longa. Direct curcumin targets include cyclooxygenase 2 (COX-2), lipoxygenase, nuclear factor erythroid 2-related factor 2, toll-like receptor (TLR)4, focal adhesion kinase, glutathione, glycogen synthase kinase- (GSK-) 3 β, phosphorylase-3 kinase, xanthine oxidase, pp60 src tyrosine kinase, and ubiquitin isopeptidase, which play an important role in oxidative stress, inflammation, autophagy, and apoptosis. Curcumin has been widely used in pharmaceutical and medical applications because of its broad spectrum of biological actions, including antibacterial, antiviral, antifungal, and anti-inflammatory activity. Based on these targets or pathways, curcumin has been proposed to increase the therapeutic efficiency of some drugs, albeit the potential molecular mechanism remains unclear. Importantly, available preclinical and phase I/II data suggest that curcumin is well tolerated and has a good safety profile. A classic example is the combination between curcumin and polymyxins whereby in addition to its synergistic antimicrobial activity, cumin could potentially ameliorate unwanted neurotoxicity induced by polymyxins. With the proposal of concept on precision medicine in the clinic, the underlying molecular mechanism and potential target for the combination therapy are much emphasized.

This special issue intends to compile original research and review articles, which address the precise molecular mechanisms based on curcumin combination therapy, as well as the new combination and discovery therapy against diseases such as cancer, inflammation, and infections. Studies focusing on the toxicology and pharmacology effects during therapy based on curcumin combination are also welcome.

Potential topics include but are not limited to the following:

  • The discovery of new combination therapy based on curcumin against infections, cancer and inflammatory disease, and the precise molecular mechanisms
  • The discovery of new targeted molecules based on curcumin combination therapy
  • The action mechanism of curcumin combination on cell apoptosis, autophagy, and inflammatory response in vivo or in vitro
  • Discoveries of new combinations between curcumin and current chemotherapy drugs
  • New findings of curcumin’s protection on the toxicology effect caused by drugs or toxins in vivo or in vitro

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 2160642
  • - Research Article

SOD2 Mediates Curcumin-Induced Protection against Oxygen-Glucose Deprivation/Reoxygenation Injury in HT22 Cells

Yuqing Wang | Yuanyuan Zhang | ... | Shuai Yang
  • Special Issue
  • - Volume 2019
  • - Article ID 1685128
  • - Research Article

The Variant at TGFBRAP1 but Not TGFBR2 Is Associated with Antituberculosis Drug-Induced Liver Injury

Jingwei Zhang | Zhenzhen Zhao | ... | Binwu Ying
  • Special Issue
  • - Volume 2019
  • - Article ID 1390795
  • - Review Article

Effects of Curcumin on Vessel Formation Insight into the Pro- and Antiangiogenesis of Curcumin

Ting-ye Wang | Jia-xu Chen
  • Special Issue
  • - Volume 2019
  • - Article ID 3648685
  • - Research Article

An Ancient Chinese Herbal Decoction Containing Angelicae Sinensis Radix, Astragali Radix, Jujuba Fructus, and Zingiberis Rhizoma Recens Stimulates the Browning Conversion of White Adipocyte in Cultured 3T3-L1 Cells

Guowei Gong | Guangyi Han | ... | Yuzhong Zheng
  • Special Issue
  • - Volume 2019
  • - Article ID 9689325
  • - Research Article

Cynomorium songaricum Extract Alleviates Memory Impairment through Increasing CREB/BDNF via Suppression of p38MAPK/ERK Pathway in Ovariectomized Rats

Fang-ze Tian | Hong-sheng Chang | ... | Yi Lu
  • Special Issue
  • - Volume 2019
  • - Article ID 2682748
  • - Review Article

Role of Gut Microbiota in the Pharmacological Effects of Natural Products

Chuyue Pan | Qinglong Guo | Na Lu
Evidence-Based Complementary and Alternative Medicine
 Journal metrics
Acceptance rate28%
Submission to final decision79 days
Acceptance to publication45 days
CiteScore2.010
Impact Factor1.984
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