Evidence-Based Complementary and Alternative Medicine

Plant-Derived Compounds as Novel Anticancer Agents


Publishing date
01 Dec 2022
Status
Published
Submission deadline
12 Aug 2022

Lead Editor
Guest Editors

1The Second Hospital of Jilin University, Changchun, China

2Academy of Scientific and Innovative Research CSIR-Indian Institute of Integrative Medicine, Srinagar, India

3Affiliated Hospital of Jining Medical University, Jining, China


Plant-Derived Compounds as Novel Anticancer Agents

Description

Cancer is the second leading cause of death. Millions of people are diagnosed with cancer each year and about 3.5 million people die of cancer annually across the globe. Plants have provided the mainstay of cancer chemotherapy over the past 40 years. Many of the anticancer drugs available have been developed from plants which are likely to continue to provide many of the lead anticancer structures. Additionally, about 80% of people in developing countries depend on traditional medicine for their primary health needs. Researchers from across the globe consistently explore diverse lead chemical scaffolds derived from plants that may be used directly or as templates for the development of new anticancer drugs.

Owing to the high mortality rate associated with cancer, and the serious adverse effects of chemotherapy and radiation therapy, many cancer patients seek alternative or complementary methods of treatment with 60% of cancer patients using vitamins or herbs as therapy. Plants have been used for treating various human and animal diseases since times immemorial. Given the vast biodiversity that is harboured by planet earth, only a minuscule quantity of the plant species present has been explored for their anticancer activities. Therefore, more research is required to identify and screen plant-derived compounds for their anticancer potential. Owing to the high demand for safer anticancer therapeutic agents and better side effects of the synthetic counterparts, natural bioactive compounds have enormous potential in the pharmaceutical industry.

Considering the importance of plants as the source of anticancer agents, this Special Issue aims to present novel findings of the metabolomic evaluation and anticancer activity of plant-derived compounds. This Special Issue calls for original research and review articles with a focus on the bioactivity and molecular mechanism of plant-derived anticancer agents.

Potential topics include but are not limited to the following:

  • Anticancer activity of plant-derived compounds in vitro and in vivo
  • Elucidation of the mechanism of action of novel plant-derived anticancer agents
  • Metabolomic evaluation of active phytoconstituents responsible for anticancer activity based on omics techniques (HPLC, GC-MS, LC-MS)
  • Apoptosis-inducing plant-derived anticancer agents
  • Cell cycle arrest triggering plant-derived anticancer agents
  • Autophagy-inducing plant-derived anticancer agents
  • Mitophagy-inducing plant-derived anticancer agents
  • Synergistic effects of plant-derived anticancer compounds
  • Effects of plant-derived anticancer agents on metastasis of cancer cells

Articles

  • Special Issue
  • - Volume 2023
  • - Article ID 9764181
  • - Retraction

Retracted: Application Value of Metagenomics Next-Generation Sequencing (mNGS) in Detection of Mucormycosis after Chemotherapy in Childhood Acute Leukemia

Evidence-Based Complementary and Alternative Medicine
  • Special Issue
  • - Volume 2023
  • - Article ID 6715978
  • - Research Article

Role of Huangqin Decoction in Intestinal Homeostasis and Colon Carcinogenesis Based on “SREBP1 Cholesterol Metabolism Treg Cell Differentiation”

Junde Zhou | Nannan Lu | ... | Lixia Ke
  • Special Issue
  • - Volume 2023
  • - Article ID 2176371
  • - Research Article

An Evaluation of Fluorouracil plus Paclitaxel and Oxiliplatin as a First-Line Treatment for Advanced Gastric Squamous Cell Carcinoma

Jie Qin | Yingpeng Shi | ... | Mi Liu
  • Special Issue
  • - Volume 2023
  • - Article ID 1266778
  • - Research Article

Clinical Study of 3DCRT Combined with SBRT in the Treatment of Patients with EGFR Mutation Oligometastatic Non-Small Cell Lung Cancer

Deng Wang | Yingbang Wan | Lihua Wang
  • Special Issue
  • - Volume 2023
  • - Article ID 7530725
  • - Research Article

Esculentoside A Inhibits Proliferation, Colony Formation, Migration, and Invasion of Human Colorectal Cancer Cells

Maha Abdullah Momenah | Layla Awad Almutairi | ... | Ahmed Ezzat Ahmed
  • Special Issue
  • - Volume 2023
  • - Article ID 4025734
  • - Research Article

Garlic Extract Participates in the Proliferation and Apoptosis of Nonsmall Cell Lung Cancer Cells Via Endoplasmic Reticulum Stress Pathway

Deguang Pan | Mingjun Zheng | ... | Xiulian Shi
  • Special Issue
  • - Volume 2023
  • - Article ID 5885387
  • - Research Article

RAB11A Promotes Cell Malignant Progression and Tumor Formation of Prostate Cancer via Activating FAK/AKT Signaling Pathway

Weifang Chen | Junjun Wang
  • Special Issue
  • - Volume 2022
  • - Article ID 7366432
  • - Research Article

[Retracted] Application Value of Metagenomics Next-Generation Sequencing (mNGS) in Detection of Mucormycosis after Chemotherapy in Childhood Acute Leukemia

Wenzi Li | Hua Zhu | ... | Li Wang
  • Special Issue
  • - Volume 2022
  • - Article ID 1150390
  • - Research Article

The Prognostic Value of AT-Rich Interaction Domain (ARID) Family Members in Patients with Hepatocellular Carcinoma

Siyi Li | Zhulin Wu | ... | Huafeng Pan
  • Special Issue
  • - Volume 2022
  • - Article ID 7983530
  • - Research Article

Study on the Diagnostic Value of Contrast-Enhanced Ultrasound and Magnetic Resonance Imaging in Prostate Cancer

Xinnian Pang | Jianhua Zhang | ... | Dong Xu

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