Evidence-Based Complementary and Alternative Medicine

Multiple Bioactivities of Traditional Medicinal Herbs for Treatment of Neurodegenerative Diseases


Publishing date
01 Dec 2017
Status
Published
Submission deadline
14 Jul 2017

Lead Editor

1Korea Institute of Oriental Medicine (KIOM), Daejeon, Republic of Korea

2Daegu Haany University, Gyeongsan, Republic of Korea

3Mulawarman University, Samarinda, Indonesia


Multiple Bioactivities of Traditional Medicinal Herbs for Treatment of Neurodegenerative Diseases

Description

Neurodegenerative diseases are debilitating and incurable conditions in the central nervous system (CNS). They are characterized by neuronal dysfunction and are often associated with atrophy of the affected nervous system structures. Age-related dementia constitutes a major subset of neurodegenerative disease. Alzheimer's disease (AD) is the most prevalent clinical form of dementia in aging populations, and 43% of individuals aged ≥ 85 years are thought to have AD in the United States. Parkinson's disease (PD), another common neurodegenerative disease prevalent among the elderly, affects 1–3% of the population aged > 60 years. The United Nations population projections have estimated a worldwide population of 400 million individuals aged ≥ 80 years by 2050 to have a neurodegenerative disease. Owing to the financial, societal, and personal impact of these diseases, etiologies, prevention, and treatment have become the major focus of basic and clinical research. Etiological studies have revealed an association between neurodegenerative diseases and genetic factors, which is variable within populations for one disease state.

Alzheimer's disease is also linked to mutation in a specific gene; however, downstream effects of its protein product on symptoms including dementia are not fully understood. Multiple signaling pathways constitute the molecular basis of the effects of genetic variation, lifestyle, and environmental factors including trauma and infection in neurodegenerative diseases. Neuropathological hallmarks of dementia include β-amyloid plaques and neurofibrillary tangles in AD and Lewy body inclusions in PD. However, while misfolded protein aggregation clearly plays a role in neurodegenerative disease, this is evidently only a signature of neuronal damage and additional causative factors remain to be discerned. The roles of inflammation and nitric oxide signaling are active areas of investigation. The effects of these and other key factors on transcriptional regulation and initiation of apoptosis and neurotoxicity continue to be intensively explored. The pathogenesis of neurodegenerative diseases remains unclear and the present one-drug, one-target paradigm for treating neurodegenerative diseases appears clinically unsuccessful.

In many papers, the pathological effects of neurodegenerative diseases are a result of altered activity in multiple pathways. Thus, new pharmacological therapeutic strategies, such as natural compounds or medicinal herbal extracts composed of multiple compounds, are designed to specifically act on multiple neural and biochemical targets.

Thus, we invite investigators to contribute brief and original articles on neurodegenerative diseases via multiple bioactivities and the potential therapeutic effects of medicinal herbs on these disorders. We are particularly interested in articles on clinical or animal-based evaluations of the effectiveness of traditional herbs, including formula.

Potential topics include but are not limited to the following:

  • Animal/clinical studies on the effectiveness of medicinal herbs against neurodegenerative diseases, including AD and PD, via apoptosis and inflammation, immune dysfunction, oxidative stress, and other factors
  • Mechanistic studies on neurodegenerative diseases and herb-derived therapeutics using animal or cellular models

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 3075458
  • - Editorial

Multiple Bioactivities of Traditional Medicinal Herbs for Treatment of Neurodegenerative Diseases

Gunhyuk Park | Irawan W. Kusuma | Yong-ung Kim
  • Special Issue
  • - Volume 2018
  • - Article ID 8941564
  • - Research Article

Neuroprotective Effect and Molecular Mechanism of [6]-Gingerol against Scopolamine-Induced Amnesia in C57BL/6 Mice

Chang-Yul Kim | Yongtaek Seo | ... | Jung-Hee Jang
  • Special Issue
  • - Volume 2017
  • - Article ID 5934254
  • - Research Article

Fuzheng Quxie Decoction Ameliorates Learning and Memory Impairment in SAMP8 Mice by Decreasing Tau Hyperphosphorylation

Yang Yang | Xingxing Jia | ... | Hao Li
  • Special Issue
  • - Volume 2017
  • - Article ID 9502067
  • - Research Article

Effects and Mechanism of Huannao Yicong Decoction Extract on the Ethology of Transgenic APP/PS1 Mice

Meixia Liu | Yun Wei | ... | Hao Li
  • Special Issue
  • - Volume 2017
  • - Article ID 6360836
  • - Research Article

Quantitative Analysis and Biological Efficacies regarding the Neuroprotective and Antineuroinflammatory Actions of the Herbal Formula Jodeungsan in HT22 Hippocampal Cells and BV-2 Microglia

Yu Jin Kim | Hye-Sun Lim | ... | Soo-Jin Jeong
  • Special Issue
  • - Volume 2017
  • - Article ID 4926815
  • - Research Article

Amelioration of Scopolamine-Induced Learning and Memory Impairment by α-Pinene in C57BL/6 Mice

Gil-Yong Lee | Chan Lee | ... | Jung-Hee Jang
  • Special Issue
  • - Volume 2017
  • - Article ID 4757520
  • - Research Article

Extract of Fructus Cannabis Ameliorates Learning and Memory Impairment Induced by D-Galactose in an Aging Rats Model

Ning-Yuan Chen | Cheng-Wu Liu | ... | Shang-Ling Pan
  • Special Issue
  • - Volume 2017
  • - Article ID 5398542
  • - Research Article

Salidroside Protects against MPP+-Induced Neuronal Injury through DJ-1-Nrf2 Antioxidant Pathway

Leitao Wu | Hang Xu | ... | Jing Ma
  • Special Issue
  • - Volume 2017
  • - Article ID 8429290
  • - Research Article

Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson’s Disease

Luiz Eduardo Mateus Brandão | Diana Aline Morais Ferreira Nôga | ... | Alessandra Mussi Ribeiro
  • Special Issue
  • - Volume 2017
  • - Article ID 3019568
  • - Review Article

A Review of Dietary Ziziphus jujuba Fruit (Jujube): Developing Health Food Supplements for Brain Protection

Jianping Chen | Xiaoyan Liu | ... | Karl W. K. Tsim
Evidence-Based Complementary and Alternative Medicine
 Journal metrics
Acceptance rate28%
Submission to final decision71 days
Acceptance to publication39 days
CiteScore2.010
Impact Factor1.984
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