With the rapid development of economy and change of lifestyle, the number of patients with hyperuricemia and gout are increasing promptly. Gout is characterized by arthritis, tophi, urolithiasis, and kidney injury. Gout and hyperuricemia are associated with obesity, diabetes, insulin resistance, hypertension, hyperlipidemia, gouty nephropathy, and nonalcoholic fatty liver disease. Conventional therapies for gout include anti-inflammation medications (colchicine, nonsteroidal anti-inflammatory drugs, and glucocorticoids) and urate-lowering therapies (allopurinol, benzbromarone, and febuxostat). However, these chemical medications are accompanied by some adverse effects. Therefore, they are restricted in clinical settings. To our knowledge, complementary and alternative medicines have unique effects in antiinflammation and lowering uric acid with few adverse effects.

In this Special Issue, we encourage more studies regarding the efficacy and safety of complementary and alternative medicines, including Chinese herbal compounds, herbal extracts, Chinese patent drugs, or acupuncture on hyperuricemia and gout-related diseases. In vivo or in vitro experiments and multicenter randomized controlled trials are welcome. Research exploring the molecular mechanisms of complementary and alternative medicine for the treatment of hyperuricemia and gout-related diseases are meaningful. Review articles that focus on investigating the crosstalk between gout, hyperuricemia and other complications will also be welcome.

Potential topics include but are not limited to the following:

• Complementary and alternative medicine for treating hyperuricemia and gout-related diseases
• Application of precision medicine in hyperuricemia and gout-related diseases
• Application of single cell sequencing technology in hyperuricemia and gout-related diseases
• Application of bioinformatics in hyperuricemia and gout-related diseases
• Application of network pharmacology in hyperuricemia and gout-related diseases
• New technologies in mining the effective materials of complementary and alternative medicine for treating hyperuricemia and gout-related diseases