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Complementary Medicine for Stimulation of Anticancer Immunity

Call for Papers

Although cancer cells are continuously generated in our body, immune surveillance system eradicates them and we can stay healthy. But, sometimes the immune surveillance system cannot work properly; the cancer cells evade it and grow as a tumor burden. Recently, cancer immunotherapy which is not targeted for tumor cells but immune cells has become an essential area for cancer treatment.

Various tumor-immunologic biologicals have been approved and cancer immunotherapy has attracted great attention. Even though there are many studies about immune regulation by complementary medicine, there are only a few studies of cancer immunotherapy by complementary medicine. Although complementary medicine has been used in clinic for cancer treatment, it is not clear yet from the stage of action mechanism. Even if it is experimentally effective, it is unknown whether it really can treat cancer by the mechanism. Therefore, there are many things to study in the future.

The purpose of this special issue is to disclose the research results with interest in natural products (extracts and isolated compounds) in the cancer immunotherapy. In addition, systematic reviews which describe the current state of the art are welcome.

We invite investigators to submit original research articles and reviews to this special issue.

Potential topics include but are not limited to the following:

  • Modulation of tumor associated macrophages (TAM) polarization by natural products or their compounds
  • Inhibition of immune checkpoints such as PD-1 and CTLA-4 by natural products or their compounds
  • Tuning of tumor microenvironment via immune cells
  • Suppression of regulatory T cells or MDSCs (myeloid-derived suppressor cell) in tumor microenvironment.
  • In vitro, in vivo, and clinical studies related to a cancer immunity by natural products
  • Antitumoral activity of herbal medicines mediated by immune cells

Authors can submit their manuscripts through the Manuscript Tracking System at

Submission DeadlineFriday, 14 December 2018
Publication DateMay 2019

Papers are published upon acceptance, regardless of the Special Issue publication date.

Lead Guest Editor

  • Hwan-Suck Chung, Korea Institute of Oriental Medicine (KIOM), Daegu, Republic of Korea

Guest Editors

  • Hongsheng Lin, China Academy of Chinese Medical Sciences, Beijing, China
  • Hyo-Jin An, Sangji University, Wonju, Republic of Korea