Evidence-Based Complementary and Alternative Medicine

Complementary and Alternative Medicine for Liver Fibrosis


Publishing date
01 Sep 2021
Status
Closed
Submission deadline
16 Apr 2021

Lead Editor

1Taipei Tzuchi Hospital, New Taipei City, Taiwan

2The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China

3University of Texas Health Science Center, San Antonio, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Complementary and Alternative Medicine for Liver Fibrosis

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Liver fibrosis is a frequent complication related to chronic liver diseases and is associated with chronic hepatocellular stress that results in cell death and activation of multiple signalling pathways. Pathogenic causes include genetic disorders, viruses, alcohol, autoimmune attacks, metabolic disorders, cholestasis, venous obstruction, and parasites. The disease pathomechanisms causing tissue damage induces an inflammatory response involving the local vascular system and the immune system and a systemic mobilization of endocrine and neurological mediators, which leads to the activation of matrix-producing cell populations. For example, the human hepatic stellate cell activation and proliferation causes excessive extracellular matrix growth leading to scar formation and fibrosis.

Liver fibrosis may have distinguishable causes from alcoholic and non-alcoholic liver disease in the Western world. A comprehensive understanding of the transition process from a healthy liver to end-stage disease is needed to enable the prediction of individual disease courses. In advanced fibrosis, the development of portal hypertension and its associated complications are determinants of the patient´s prognosis, but these processes are still incompletely understood. The practice of complementary and alternative medicines (CAMs) is involved in various fields. To our knowledge, there are some mainstream and accepted therapies of fields including traditional alternative medicine, healing by touch approach, diet and herbs, external energy, and even mental health.

This Special Issue aims to highlight the latest research that will help in the development of CAMs to prevent and treat liver fibrosis. We invite authors to submit original research and review articles regarding relevant CAMs for the molecular/cellular aspects of liver fibrosis.

Potential topics include but are not limited to the following:

  • Hepatic stellate cells in liver fibrosis
  • Non-alcoholic fatty liver disease
  • Gut–liver axis: how do gut bacteria influence the liver?
  • Cell death in drug-induced liver injury
  • Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease
  • Alcohol-related liver injury
  • Phase transition
  • Portal hypertension caused by liver disease
  • Liver cirrhosis
  • Cytokine signalling pathway under liver disease
  • Hepatic-derived chemokines
  • In vitro and in vivo models to validate promising CAMs to prevent and treat liver fibrosis
  • Immunology in hepatic fibrosis
  • Fibrosis and reliable CAMs
  • NASH/NAFLD

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 9967910
  • - Research Article

Alleviative Effect of Ruellia tuberosa L. on Insulin Resistance and Abnormal Lipid Accumulation in TNF-α-Treated FL83B Mouse Hepatocytes

Hong-Jie Chen | Chih-Yuan Ko | ... | Szu-Chuan Shen
  • Special Issue
  • - Volume 2021
  • - Article ID 6671129
  • - Research Article

Wild Bitter Melon Extract Regulates LPS-Induced Hepatic Stellate Cell Activation, Inflammation, Endoplasmic Reticulum Stress, and Ferroptosis

Chang-Hsun Ho | Jen-Hsuan Huang | ... | Chan-Yen Kuo
  • Special Issue
  • - Volume 2021
  • - Article ID 5525369
  • - Research Article

Lower Somatic Mutation Levels in the λ Light-Chain Repertoires with Chronic HBV Infection

Binbin Hong | Qiaoling Liu | ... | Lizhi Wang
  • Special Issue
  • - Volume 2021
  • - Article ID 9931542
  • - Research Article

Quantitative Profiling of Oxylipin Reveals the Mechanism of Pien-Tze-Huang on Alcoholic Liver Disease

Ziye Zhu | Wenjun Zhou | ... | Yanqi Dang
  • Special Issue
  • - Volume 2021
  • - Article ID 5522755
  • - Research Article

Jian-Gan-Xiao-Zhi Decoction Alleviates Inflammatory Response in Nonalcoholic Fatty Liver Disease Model Rats through Modulating Gut Microbiota

Jiabao Liao | Xuehua Xie | ... | Hongwu Wang
  • Special Issue
  • - Volume 2021
  • - Article ID 5574010
  • - Research Article

Astragali Radix Contributes to the Inhibition of Liver Fibrosis via High-Mobility Group Box 1-Mediated Inflammatory Signaling Pathway

Jianxia Wen | Dan Wang | ... | Yanling Zhao
  • Special Issue
  • - Volume 2021
  • - Article ID 6655335
  • - Review Article

Hepatocardiac or Cardiohepatic Interaction: From Traditional Chinese Medicine to Western Medicine

Yaxing Zhang | Xian-Ming Fang
  • Special Issue
  • - Volume 2021
  • - Article ID 6661667
  • - Research Article

Network Pharmacology-Based Study on the Molecular Biological Mechanism of Action for Qingdu Decoction against Chronic Liver Injury

Chongyang Ma | Mengpei Zhao | ... | Lianyin Gao
  • Special Issue
  • - Volume 2020
  • - Article ID 6612447
  • - Research Article

The Association between Metabolic Syndrome and Elevated Alanine Aminotransferase Levels in an Indigenous Population in Northern Taiwan: A Community-Based and Cross-Sectional Study

Yi-Fang Chen | Yen-An Lin | ... | Jau-Yuan Chen
  • Special Issue
  • - Volume 2020
  • - Article ID 6644253
  • - Research Article

Identification of Bioactive Components from Ruellia tuberosa L. on Improving Glucose Uptake in TNF-α-Induced Insulin-Resistant Mouse FL83B Hepatocytes

Jian-Hua Xu | Yangming Martin Lo | ... | Szu-Chuan Shen
Evidence-Based Complementary and Alternative Medicine
 Journal metrics
Acceptance rate27%
Submission to final decision68 days
Acceptance to publication33 days
CiteScore3.000
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Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.