Sedation in Traumatic Brain Injury

Table 1

Abbreviations and explanations

(i) AMPA: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, GABA: γ-Aminobutyric acid; (ii) EEG: Electroencephalogram; (iii) CMRO2: Cerebral Metabolic Rate of Oxygen; (iv) CPP: Cerebral Perfusion Pressure; (v) ICP: Intracranial Pressure; (vi) IV: Intravenous; (vii) MAP: Mean Arterial Pressure; (viii) 𝑡1/2: Half-life; (ix) Context sensitive 𝑡1/2: the time taken for blood plasma concentration of a drug to decline by one half after an infusion designed to maintain a steady state (i.e., a constant plasma concentration) has been stopped. The “context” is the duration of infusion [5].