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Emergency Medicine International
Volume 2014, Article ID 242171, 7 pages
http://dx.doi.org/10.1155/2014/242171
Research Article

A Bioclinical Pattern for the Early Diagnosis of Cardioembolic Stroke

1Emergency Care Unit, Fondazione IRCCS Ca’ Granda OspedaleMaggiore Policlinico, Via F. Sforza 35, 20100 Milan, Italy
2Università degli Studi di Milano, Via Festa del Perdono 7, 20100 Milan, Italy
3Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20100 Milan, Italy
4Cardiovascular Disease Institute, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20100 Milan, Italy
5Epidemiology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20100 Milan, Italy
6Scientific Direction, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20100 Milan, Italy

Received 27 September 2013; Revised 15 January 2014; Accepted 19 January 2014; Published 5 March 2014

Academic Editor: Massimo Gallerani

Copyright © 2014 Bruno Zecca et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. P. Adams Jr., B. H. Bendixen, L. J. Kappelle et al., “Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial,” Stroke, vol. 24, no. 1, pp. 35–41, 1993. View at Google Scholar · View at Scopus
  2. J. K. Jensen, D. Atar, S. R. Kristensen, H. Mickley, and J. L. Januzzi Jr., “Usefulness of natriuretic peptide testing for long-term risk assessment following acute ischemic stroke,” The American Journal of Cardiology, vol. 104, no. 2, pp. 287–291, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. A. M. Mäkikallio, T. H. Mäkikallio, J. T. Korpelainen et al., “Natriuretic peptides and mortality after stroke,” Stroke, vol. 36, no. 5, pp. 1016–1020, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Montaner, T. Garcia-Berrocoso, M. Mendioroz et al., “Brain natriuretic peptide is associated with worsening and mortality in acute stroke patients but adds no prognostic value to clinical predictors of outcome,” Cerebrovascular Diseases, vol. 34, pp. 240–245, 2012. View at Google Scholar
  5. K. Nakagawa, T. Yamaguchi, M. Seida et al., “Plasma concentrations of brain natriuretic peptide in patients with acute ischemic stroke,” Cerebrovascular Diseases, vol. 19, no. 3, pp. 157–164, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Tomita, N. Metoki, G. Saitoh et al., “Elevated plasma brain natriuretic peptide levels independent of heart disease in acute ischemic stroke: correlation with stroke severity,” Hypertension Research, vol. 31, no. 9, pp. 1695–1702, 2008. View at Google Scholar · View at Scopus
  7. W. Whiteley, J. Wardlaw, M. Dennis et al., “Blood biomarkers for the diagnosis of acute cerebrovascular diseases: a prospective cohort study,” Cerebrovascular Diseases, vol. 32, no. 2, pp. 141–147, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Shibazaki, K. Kimura, Y. Iguchi, Y. Okada, and T. Inoue, “Plasma brain natriuretic peptide can be a biological marker to distinguish cardioembolic stroke from other stroke types in acute ischemic stroke,” Internal Medicine, vol. 48, no. 5, pp. 259–264, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. K. Yukiiri, N. Hosomi, T. Naya et al., “Plasma brain natriuretic peptide as a surrogate marker for cardioembolic stroke,” BMC Neurology, vol. 8, article 45, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Montaner, M. Perea-Gainza, P. Delgado et al., “Etiologic diagnosis of ischemic stroke subtypes with plasma biomarkers,” Stroke, vol. 39, no. 8, pp. 2280–2287, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Naya, K. Yukiiri, N. Hosomi et al., “Brain natriuretic peptide as a surrogate marker for cardioembolic stroke with paroxysmal atrial fibrillation,” Cerebrovascular Diseases, vol. 26, no. 4, pp. 434–440, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Rodríguez-Yáez, T. Sobrino, M. Blanco et al., “High serum levels of pro-brain natriuretic peptide (pro BNP) identify cardioembolic origin in undetermined stroke,” Disease Markers, vol. 26, no. 4, pp. 189–195, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Danesh, R. Collins, P. Appleby, and R. Peto, “Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies,” Journal of the American Medical Association, vol. 279, no. 18, pp. 1477–1482, 1998. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Djoussé, K. J. Rothman, L. A. Cupples, D. Levy, and R. C. Ellison, “Serum albumin and risk of myocardial infarction and all-cause mortality in the framingham offspring study,” Circulation, vol. 106, no. 23, pp. 2919–2924, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. K. J. Mukamal, J. S. Tolstrup, J. Friberg, M. Grønbaek, and G. Jensen, “Fibrinogen and albumin levels and risk of atrial fibrillation in men and women (the copenhagen city heart study),” The American Journal of Cardiology, vol. 98, no. 1, pp. 75–81, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. R. F. Gillum, D. D. Ingram, and D. M. Makuc, “Relation between serum albumin concentration and stroke incidence and death: the NHANES I epidemiologic follow-up study,” American Journal of Epidemiology, vol. 140, no. 10, pp. 876–888, 1994. View at Google Scholar · View at Scopus
  17. F. J. Alvarez-Perez, M. Castelo-Branco, and J. Alvarez-Sabin, “Usefulness of measurement of fibrinogen, D-dimer, D-dimer/fibrinogen ratio, C reactive protein and erythrocyte sedimentation rate to assess the pathophysiology and mechanism of ischaemic stroke,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 82, no. 9, pp. 986–992, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. D. S. G. Conway, P. Buggins, E. Hughes, and G. Y. H. Lip, “Relationship of interleukin-6 and C-reactive protein to the prothrombotic state in chronic atrial fibrillation,” Journal of the American College of Cardiology, vol. 43, no. 11, pp. 2075–2082, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. D. S. G. Conway, P. Buggins, E. Hughes, and G. Y. H. Lip, “Prognostic significance of raised plasma levels of interleukin-6 and C-reactive protein in atrial fibrillation,” American Heart Journal, vol. 148, no. 3, pp. 462–466, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. L. B. Goldstein and G. P. Samsa, “Reliability of the National Institutes of Health Stroke Scale: extension to non-neurologists in the context of a clinical trial,” Stroke, vol. 28, no. 2, pp. 307–310, 1997. View at Google Scholar · View at Scopus
  21. J. Bamford, P. Sandercock, M. Dennis, J. Burn, and C. Warlow, “Classification and natural history of clinical identifiable subtypes of cerebral infarction,” The Lancet, vol. 337, no. 8756, pp. 1521–1526, 1991. View at Publisher · View at Google Scholar · View at Scopus
  22. N. C. Davidson, A. A. Naas, J. K. Hanson, N. S. J. Kennedy, W. J. Coutie, and A. D. Struthers, “Comparison of atrial natriuretic peptide, B-type natriuretic peptide, and N-termmal proatrial natriuretic peptide as indicators of left ventricular systolic dysfunction,” The American Journal of Cardiology, vol. 77, no. 10, pp. 828–831, 1996. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Omland, A. Aakvaag, and H. Vik-Mo, “Plasma cardiac natriuretic peptide determination as a screening test for the detection of patients with mild left ventricular impairment,” Heart, vol. 76, no. 3, pp. 232–237, 1996. View at Google Scholar · View at Scopus
  24. E. Cecchi, R. Marcucci, D. Poli et al., “Hyperviscosity as a possible risk factor for cerebral ischemic complications in atrial fibrillation patients,” The American Journal of Cardiology, vol. 97, no. 12, pp. 1745–1748, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Kurl, M. Ala-Kopsala, H. Ruskoaho et al., “Plasma N-terminal fragments of natriuretic peptides predict the risk of stroke and atrial fibrillation in men,” Heart, vol. 95, no. 13, pp. 1067–1071, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. M. K. Chung, D. O. Martin, D. Sprecher et al., “C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation,” Circulation, vol. 104, no. 24, pp. 2886–2891, 2001. View at Google Scholar · View at Scopus
  27. S. Kamath, A. D. Blann, B. S. P. Chin, and G. Y. H. Lip, “Platelet activation, haemorheology and thrombogenesis in acute atrial fibrillation: a comparison with permanent atrial fibrillation,” Heart, vol. 89, no. 9, pp. 1093–1095, 2003. View at Google Scholar · View at Scopus
  28. B. M. Coull, N. Beamer, P. de Garmo et al., “Chronic blood hyperviscosity in subjects with acute stroke, transient ischemic attack, and risk factors for stroke,” Stroke, vol. 22, no. 2, pp. 162–168, 1991. View at Google Scholar · View at Scopus
  29. T. García-Berrocoso, I. Fernández-Cadenas, P. Delgado, A. Rosell, and J. Montaner, “Blood biomarkers in cardioembolic stroke,” Current Cardiology Reviews, vol. 6, no. 3, pp. 194–201, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. P. Amarenco, J. Bogousslavsky, L. R. Caplan, G. A. Donnan, and M. G. Hennerici, “New approach to stroke subtyping: the A-S-C-O (phenotypic) classification of stroke,” Cerebrovascular Diseases, vol. 27, no. 5, pp. 502–508, 2009. View at Publisher · View at Google Scholar · View at Scopus