Special management of life-threatening bleeding in patients receiving rivaroxaban. *Refers to information including timing of last dose of rivaroxaban, dose administered, and risk factors for bleeding (i.e., renal/hepatic function and concomitant medication). †After 10–15 minutes. ‡Prothrombotic risk may be higher with aPCC or rFVIIa. aPCC = activated prothrombin complex concentrate; PCC = prothrombin complex concentrate; PT = prothrombin time; rFVIIa = recombinant activated Factor VII.
