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Emergency Medicine International
Volume 2018, Article ID 3296535, 6 pages
Research Article

The Diagnostic Value of Irisin in Pediatric Patients with Acute Abdominal Pain

1Department of Pediatric Surgery, Haseki Research and Education Hospital, Istanbul, Turkey
2Department of Pediatric Surgery, Cengiz Gökcek Obstetrics and Children’s Hospital, Gaziantep, Turkey
3Department of Emergency Medicine, Haseki Research and Education Hospital, Istanbul, Turkey
4Department of Pediatrics, Haseki Research and Education Hospital, Istanbul, Turkey
5Department of Biochemistry, Haseki Research and Education Hospital, Istanbul, Turkey
6Department of General Surgery, Haseki Research and Education Hospital, Istanbul, Turkey
7Department of Emergency Medicine, Bagcilar Research and Education Hospital, Istanbul, Turkey

Correspondence should be addressed to Fatma Sarac; moc.liamg@57carasf

Received 5 March 2018; Revised 2 August 2018; Accepted 28 August 2018; Published 24 September 2018

Academic Editor: Seiji Morita

Copyright © 2018 Fatma Sarac et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. Diagnosis of pediatric patients presenting to the Emergency Department with acute abdominal pain is not always easy. The purpose of this study was to investigate the effectiveness of irisin, a peptide hormone with reactivity shown in the appendix and neutrophils, in the differential diagnosis of pediatric patients with acute abdominal pain. Methods. 162 subjects consenting to participate, including 112 patients presenting to the Pediatric Emergency and Pediatric Surgery clinics with acute abdominal pain and 50 controls, were enrolled in the study. Blood was collected from all patients following initial examination for irisin, WBC, and CRP investigation. Results. Mean irisin levels in cases of acute appendicitis (AA) and perforated appendicitis (PA) were statistically significantly higher compared to nonspecific abdominal pains and the control group. No statistically significant difference was observed in irisin levels between AA and PA cases. WBC and CRP levels were also significantly higher in cases of AA and PA compared to nonspecific abdominal pains. Conclusions. Differential diagnosis of acute abdominal pains in children and deciding on surgery are a difficult and complex process. Our study shows that irisin can be a useful biomarker in differentiating AA and PA from other acute abdominal pains in children.