Predictive Factors and Clinical Prediction Score for Serious Intracranial Causes in Acute Nontraumatic Headache at an Emergency Department

Table 4

Multivariable logistic regression model for the predictive factors of serious intracranial cause in acute nontraumatic headache.

Variables	Crude OR (95% CI)	Adjusted OR (95% CI)	value
Abrupt onset	3.19 (1.9–5.33)	7.96 (2.77–22.91)	<0.001
Awakening pain	7.24 (4.26–12.29)	3.14 (4.15–6.82)	0.004
Duration >1 week	4.06 (2.12–7.78)	10.59 (2.9–38.7)	<0.001
Fever	4.36 (2.33–8.15)	6.01 (2.07–17.46)	<0.001
Worst headache ever	35 (17.57–69.71)	12.95 (5.69–29.45)	<0.001
Alteration of consciousness	40.33 (11.74–138.6)	13.55 (2.07–88.88)	0.002
Localizing neurological deficit	8.36 (3.96–17.63)	5.28 (1.6–17.46)	0.019

values <0.05 are statistically significant. OR = odds ratio; CI = confidence interval.