Research Article
Colorectal Perforation in Patients with Connective Tissue Disease
Table 4
Clinicopathological factors in patients with and without connective tissue disease (CTD).
| | | CTD group (n=26) | Non-CTD group (n=79) | p-value |
| | 1. Patients backgrounds | | | |
| | Age | 61.5 (28 - 95) | 63 (18 – 94) | 0.70 | | Gender (Male/Female) | 7 (26.9%)/19 (73.1%) | 44 (55.7%)/35 (44.3%) | 0.01 | | Preoperative comorbidity † | | | | | Neurological disease (+/-) | 1 (3.8%)/25 (96.2%) | 11 (13.9%)/68 (86.1%) | 0.29 | | Cardiovascular disease (+/-) | 4 (15.4%)/22 (84.6%) | 10 (12.7%)/69 (87.3%) | 0.74 | | Respiratory disease (+/-) | 2 (7.7%)/24 (92.3%) | 10 (12.7%)/69 (87.3%) | 0.73 | | Gastroenterological disease (+/-) | 5 (19.2%)/21 (80.8%) | 10 (12.7%)/69 (87.3%) | 0.52 | | Renal disease (+/-) | 5 (19.2%)/21 (80.8%) | 7 (8.9%)/72 (91.1%) | 0.17 | | Hematological disease (+/-) | 1 (3.8%)/25 (96.2%) | 2 (2.5%)/77 (97.5%) | 1.00 | | Endocrinological disease (+/-) | 2 (7.7%)/24 (92.3%) | 10 (12.7%)/69 (87.3%) | 0.73 | | Diabetes Mellitus (+/-) | 7 (26.9%)/19 (73.1%) | 13 (16.5%)/66 (83.5%) | 0.26 | | Hypertension (+/-) | 3 (11.5%)/23 (88.5%) | 22 (27.8%)/57 (72.2%) | 0.11 |
| | 2. Preoperative status | | | |
| | WBC (/mm3) | 9450 (1100 - 37400) | 8700 (1700 - 28800) | 0.74 | | CRP (mg/dl) | 13.3 (0.6 - 43.5) | 12.9 (0.1 - 48.9) | 0.39 | | SIRS (+/-) | 16 (61.5%)/10 (38.5%) | 38 (48.1%)/41 (51.9%) | 0.26 |
| | 3. Surgical factors | | | |
| The time from onset of symptoms
to operation (> 12hr/≤12hr) | 15 (57.7%)/11 (42.3%) | 44 (55.7%)/35 (44.3%) | 1.00 | | Perforation site (C-T/D-R) | 10 (38.5%)/16 (61.5%) | 19 (24.1%)/60 (75.9%) | 0.21 | | Fecal peritonitis (+/-) | 7 (26.9%)/19 (73.1%) | 28 (35.4%)/51 (64.6%) | 0.48 |
| | 4. Postoperative status | | | |
| | WBC on POD 1 (/mm3) | 8400 (900 - 39900) | 9100 (700 - 40300) | 0.83 | | CRP on POD 1 (mg/dl) | 15.2 (2.3 - 37.8) | 15.7 (0.2 - 35.9) | 0.68 | | Blood culture (+/-) †† | 14 (63.6%)/8 (36.4%) | 11 (32.1%)/45 (67.9%) | < 0.001 | | DIC (+/-) | 13 (50.0%)/13 (50.0%) | 21 (26.6%)/58 (73.4%) | 0.03 | | PMX-DHP (+/-) | 13 (50.0%)/13 (50.0%) | 26 (32.9%)/53 (67.1%) | 0.16 |
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Median (min-max), † with some duplications, and †† blood culture was carried out in 78 patients. WBC: white blood cell. CRP: C-reactive protein. SIRS: systemic inflammatory response syndrome. C-T: Cecum-Transverse colon. D-R: Descending colon-rectum. POD: postoperative day. DIC: disseminated intravascular coagulation. PMX-DHP: polymyxin B-immobilized fiber column hemoperfusion. |
