Research Article
Colorectal Perforation in Patients with Connective Tissue Disease
Table 5
Clinicopathological factors in survivors and nonsurvivors among patients with connective tissue disease (CTD).
|
| Survivor group (n=21) | Non-survivor group (n=5) | p-value |
| | 1. Patients backgrounds | | | |
| | Age | 61 (38 - 83) | 73 (28 - 95) | 0.16 | | Gender (Male/Female) | 5 (23.8%)/16 (76.2%) | 2 (40.0%)/3 (60.0%) | 0.59 | | Preoperative comorbidity † | | | | | Neurological disease (+/-) | 1 (4.8%)/20 (95.2%) | 0 (0%)/5 (100%) | 1.00 | | Cardiovascular disease (+/-) | 4 (19.0%)/17 (81.0%) | 0 (0%)/5 (100%) | 0.56 | | Respiratory disease (+/-) | 2 (9.5%)/19 (90.5%) | 0 (0%)/5 (100%) | 1.00 | | Gastroenterological disease (+/-) | 3 (14.3%)/18 (85.7%) | 2 (40.0%)/3 (60.0%) | 0.24 | | Renal disease (+/-) | 4 (19.0%)/17 (81.0%) | 1 (20.0%)/4 (80.0%) | 1.00 | | Hematological disease (+/-) | 1 (4.8%)/20 (95.2%) | 0 (0%)/5 (100%) | 1.00 | | Endocrinological disease (+/-) | 2 (9.5%)/19 (90.5%) | 0 (0%)/5 (100%) | 1.00 | | Diabetes Mellitus (+/-) | 5 (23.8%)/16 (76.2%) | 2 (40.0%)/3 (60.0%) | 0.59 | | Hypertension (+/-) | 2 (9.5%)/19 (90.5%) | 1 (20.0%)/4 (80.0%) | 0.49 |
| | 2. Preoperative status | | | |
| | WBC (/mm3) | 9500 (1600 - 18100) | 7700 (1100 - 37400) | 0.79 | | CRP (mg/dl) | 9.7 (0.6 - 43.5) | 16.9 (3.0 - 32.0) | 0.72 | | SIRS (+/-) | 12 (57.1%)/9 (42.9%) | 4 (80.0%)/1 (20.0%) | 0.62 | | Dose of steroids (mg/day) | 15 (2 - 45) | 11 (3 - 24) | 0.43 | | Accumulated steroid dose (mg/month) | 420 (60 - 750) | 330 (60 - 881.5) | 0.77 | | Duration of CTD (year) | 13 (0.2 - 29) | 1.8 (1.1 - 9.0) | 0.055 | | Duration of steroid intake (year) | 9.3 (0.04 - 29) | 1.8 (0.8 – 9.0) | 0.26 | | Steroid pulse therapy (+/-) | 4 (19.0%)/17 (81.0%) | 1 (20.0%)/4 (80.0%) | 1.00 | | Immunosuppressive agent (+/-) | 5 (23.8%)/16 (76.2%) | 3 (60.0%)/2 (40.0%) | 0.15 |
| | 3. Surgical factors | | | |
| The time from onset of symptoms
to operation (> 12hr/≤12hr) | 13 (61.9%)/8 (38.1%) | 2 (40.0%)/3 (60.0%) | 0.33 | | Perforation site (C-T/D-R) | 9 (42.9%)/12 (57.1%) | 1 (20.0%)/4 (80.0%) | 0.62 | | Fecal peritonitis (+/-) | 3 (14.3%)/18 (85.7%) | 4 (80.0%)/1 (20.0%) | 0.01 |
| | 4. Postoperative status | | | |
| | WBC on POD 1 (/mm3) | 9800 (2500 - 33200) | 5600 (900 - 39900) | 0.24 | | CRP on POD 1 (mg/dl) | 15.2 (2.3 - 37.8) | 12.2 (6.6 - 27.1) | 0.77 | | Blood culture (+/-) †† | 12 (63.2%)/7 (36.8%) | 2 (66.7%)/1 (33.3%) | 1.00 | | DIC (+/-) | 10 (47.6%)/11 (52.4%) | 3 (60.0%)/2 (40.0%) | 1.00 | | PMX-DHP (+/-) | 10 (47.6%)/11 (52.4%) | 3 (60.0%)/2 (40.0%) | 1.00 | | Postoperative dose of steroids (mg/day) | 30 (5 - 86.5) | 20 (10 - 45) | 0.60 |
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Median (min-max), † with some duplications, and †† blood culture was carried out in 22 patients. WBC: white blood cell. CRP: C-reactive protein. SIRS: systemic inflammatory response syndrome. C-T: Cecum-Transverse colon. D-R: Descending colon-Rectum. POD: postoperative day. DIC: disseminated intravascular coagulation. PMX-DHP: polymyxin B-immobilized fiber column hemoperfusion. |
