Research Article
Increased Serum Concentrations of TNF-Like Weak Inducer of Apoptosis Predict Higher 28-Day Mortality in Patients with Sepsis
Table 1
Characteristics of included septic patients.
| | | Total (n=79) | Survivors (n=60) | Non-survivors (n=19) | P value |
| | Age, years | 66.6 ± 17.0 | 64.2 ± 17.8 | 74.2 ± 11.6 | 0.025 | | Gender, male(n,%) | 55 (69.6%) | 38 (63.3%) | 17 (89.5%) | 0.031 | | MAP(mmHg) | 81.0 (IQR 75.0-90.0) | 82.5 (IQR 76.0-91.5) | 80.0 (IQR 74.0-90.0) | 0.650# | | CRRT (n, %) | 14 (17.7%) | 10 (16.7%) | 4 (21.1%) | 0.733 | | Creatinine (umol/L) | 100.0 (IQR 62.0-162.0) | 89.75 (IQR 62.00-152.75) | 134.0 (IQR 103.0-192.0) | 0.072# | | Bilirubin (umol/L) | 18.0 (IQR 11.8-34.0) | 18.0 (IQR 12.0-28.1) | 20.0 (IQR 10.8-80.0) | 0.281# | | APACHE II | 15.0 (IQR 10.0-22.0) | 15.0 (IQR 9.0-18.0) | 23.0 (IQR 12.0-28.0) | 0.010# | | SOFA | 5.0 (IQR 3.0-9.0) | 4.0 (IQR 3.0-6.0) | 9.0 (IQR 4.0-13.0) | 0.001# | | Lactate (mmol/L) | 2.0 (IQR 1.1-3.5) | 1.55 (IQR 1.00-2.88) | 3.5 (IQR 2.3-6.1) | 0.001# | | CRP (mg/L) | 154.3 ± 81.7 | 157.5 ± 80.0 | 144.2 ± 89.2 | 0.540 | | Procalcitonin (ng/ml) | 5.20 (IQR 0.66-20.00) | 5.20 (IQR 0.66-12.23) | 4.69 (IQR 0.69-25.00) | 0.757# | | NT-proBNP (pg/ml) | 1276.0 (IQR 627.0-6100.0) | 1052.5 (IQR 388.5-4219.0) | 6100.0 (IQR 1152.0-25000.0) | 0.007# | | TWEAK at admission (pg/ml) | 417.4 ± 196.7 | 425.1 ± 193.2 | 393.0 ± 210.9 | 0.539 | | TWEAK in the 3rd day of admission (pg/ml) | 380.6 ± 164.1 | 357.7 ± 153.8 | 452.9 ± 178.2 | 0.026 |
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MAP, mean arterial blood pressure. CRRT, continuous renal replacement therapy. APACHE II, Acute Physiology and Chronic Health Evaluation score. SOFA, Sequential Organ Failure Assessment. CRP, C-reactive protein. NT-proBNP, N-terminal pro-B-type natriuretic peptide. TWEAK, Tumor Necrosis Factor Weak Inducer of Apoptosis. IQR, interquartile range.
#Mann-Whitney U test
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