Increased Serum Concentrations of TNF-Like Weak Inducer of Apoptosis Predict Higher 28-Day Mortality in Patients with Sepsis

Table 2

Diagnostic performances of 3 routine biomarkers (lactate, NT-proBNP and CRP), ΔTWEAK and combinative index (ΔTWEAK concentrations and lactate) for prognosis of patients with sepsis.

Indicators	AUROC (95% CI)	Cut-off value	Sensitivity (%)	Specificity (%)	LR+	LR-
Lactate	0.746 (0.636-0.837)	2.2 mmol/L	63.3 (49.9-75.4)	79.0 (54.4-93.9)	3.01	0.46
procalcitonin	0.524 (0.408-0.637)	12.3 ng/ml	76.7 (64.0-86.6)	42.1 (20.3-66.5)	1.32	0.55
CRP	0.534 (0.418-0.647)	62.5 mg/L	86.7 (75.4 – 94.1)	36.8 (16.3 – 61.6)	1.37	0.36
ΔTWEAK	0.754 (0.645-0.844)	12.0 pg/ml	68.3 (55.0-79.7)	84.2 (60.4-96.6)	4.33	0.38
Combinative index	0.860 (0.763-0.928)	0.7759	76.7 (64.0-86.6)	84.2 (60.4-96.6)	4.86	0.28

CRP, C-reactive protein; TWEAK, Tumor Necrosis Factor Weak Inducer of Apoptosis; AUROC, area under the receiver operating characteristic curve; LR, likelihood ratio.
ΔTWEAK concentrations refer to dynamic changes of TWEAK concentrations between 1st day and 3rd day of admission to ICU.