Contribution of Experimental Animal Research Studies to the Emergency Medicine Literature

Table 4

The most influential experimental animal studies in the emergency medicine literature.

Rank	Journal	Year; of Publication	First; Author	Title	Number; of; Citations	Country
1	Resuscitation	2008	Jia X.	Improving neurological outcomes post-cardiac arrest in a rat model: Immediate hypothermia and quantitative EEG monitoring	86	USA
2	Resuscitation	2008	Zhao D.	Intra-arrest cooling with delayed reperfusion yields higher survival than earlier normothermic resuscitation in a mouse model of cardiac arrest	78	USA
3	Injury	2010	Zhang X.	Chlorogenic acid protects mice against lipopolysaccharide-induced acute lung injury	76	China
4	Resuscitation	2009	Yang CH.	Dexmedetomidine–ketamine combination mitigates acute lung injury in haemorrhagic shock rats	59	Taiwan
5	Resuscitation	2010	White NJ.	Coagulopathy and traumatic shock: Characterizing hemostatic function during the critical period prior to fluid resuscitation	54	USA
6	Injury	2011	Adamskaya N.	Light therapy by blue LED improves wound healing in an excision model in rats	53	Austria
7	Injury	2011	Kanthan SR.	Platelet-rich plasma (PRP) enhances bone healing in non-united critical-sized defects: A preliminary study involving rabbit models	51	Malaysia
8	Injury	2009	Klaue K.	Bone regeneration in long-bone defects: tissue compartmentalization? In vivo study on bone defects in sheep	49	Switzerland
9	Resuscitation	2013	Sutton RM.	Hemodynamic directed CPR improves short-term survival from asphyxia-associated cardiac arrest	47	USA
10	Resuscitation	2008	Angelos Mark G.	Cardiovascular response to epinephrine varies with increasing duration of cardiac arrest	45	USA
11	Resuscitation	2010	Gotberg M.	Mild hypothermia reduces acute mortality and improves hemodynamic outcome in a cardiogenic shock pig model	45	Sweden
12	Resuscitation	2012	Hoskins; SL.	Pharmacokinetics of intraosseous and central venous drug delivery during cardiopulmonary resuscitation	44	USA
13	Injury	2010	Hakimi M.	Combined use of platelet-rich plasma and autologous bone grafts in the treatment of long bone defects in mini-pigs	44	Germany
14	Acad Emerg Med	2008	Perez E.	Determining the Optimal Dose of Intravenous Fat Emulsion for the Treatment of Severe Verapamil Toxicity in a Rodent Model	43	USA
15	Am J Emerg Med	2009	Wu JY.	A comparison of 2 types of chest compressions in a porcine model of cardiac arrest	42	China
16	Resuscitation	2012	Aksu U.	Balanced vs unbalanced crystalloid resuscitation in a near-fatal model of hemorrhagic shock and the effects on renal oxygenation, oxidative stress, and inflammation	42	Netherlands
17	Resuscitation	2010	Solevag AL.	Extended series of cardiac compressions during CPR in a swine model of perinatal asphyxia	42	Norway
18	Acad Emerg Med	2011	Littlejohn; LF.	Comparison of Celox-A, ChitoFlex, WoundStat, and Combat Gauze Hemostatic Agents Versus Standard Gauze Dressing in Control of Hemorrhage in a Swine Model of Penetrating Trauma	41	USA
19	Ann Emerg Med	2010	Niiya; T.	Intravenous Lipid Emulsion Sequesters Amiodarone in Plasma and Eliminates Its Hypotensive Action in Pigs	40	Finland
20	Resuscitation	2010	Wang H.	Intra-arrest selective brain cooling improves success of resuscitation in a porcine model of prolonged cardiac arrest	39	USA
21	Resuscitation	2008	Ristagno G.	Cerebral cortical microvascular flow during and following cardiopulmonary resuscitation after short duration of cardiac arrest	39	USA
22	Resuscitation	2008	Hutchens MP.	Soluble epoxide hydrolase gene deletion reduces survival after cardiac arrest and cardiopulmonary resuscitation	39	USA
23	Resuscitation	2014	Osredkar; D.	Hypothermia is not neuroprotective after infection-sensitized neonatal hypoxic-ischemic brain injury	38	Norway
24	Resuscitation	2012	Kim K.	Effect of valproic acid on acute lung injury in a rodent model of intestinal ischemia reperfusion	37	USA
25	Ann Emerg Med	2010	Bebarta VS.	Hydroxocobalamin and Sodium Thiosulfate Versus Sodium Nitrite and Sodium Thiosulfate in the Treatment of Acute Cyanide Toxicity in a Swine (Sus scrofa) Model	37	USA